SO SÁNH HIỆU QUẢ KHỞI MÊ, THOÁT MÊ VÀ TÁC DỤNG TRÊN TUẦN HOÀN GIỮA GÂY MÊ KẾT HỢP PROPOFOL TCI VỚI KETAMIN VÀ ETOMIDAT VỚI SEVOFLURAN Ở NGƯỜI CAO TUỔI

Abstract

The primary objective of this study was to compare the duration of anesthesia, conscious time and the effects on heart rate, blood pressure during anesthesia with propofol TCI combined with ketamine and etomidat combined with sevofluran in the elderly. 210 patients over 60 years old, ASA I and II undergoing general anesthesia and endotracheal intubation for elective surgery, were randomized to three groups: Group 1 induced with propofol TCI-Cp combined ketamin 0.3 mg/kg (n = 70), Group 2 induced with propofol TCI-Ce combined ketamin 0,3 mg/kg (n = 70); Group 3 induced with etomidat 2mg/ml intravenous rate 0,05 mg/kg/minute (n = 70). All three groups received fentanyl 3 µg/kg + esmeron 0.8 mg/kg. Results: The average onset time of lost senses, intubation and anesthesia of group 3 was shorter than that of group 1 and group 2 (p < 0,01). At the time before intubation: SBP, MAP of group 1 was lower than that of group 2 and group 3 with p < 0,05. At time after intubation: HR, SBP, MAP of group 3 was higher than those of group 1, group 2 and higher than before induction of anesthesia. Time extubation of group 1, 2 were shorter than that of group 3.