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Date Published: 17/10/2022
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DOI: https://doi.org/10.51298/vmj.v519i1.3559
Issue
Vol. 519 No. 1 (2022)
Section
Các bài báo
How to Cite
Thị Cẩm Luyến, P. ., Thị Anh, H. ., Quí Phương Linh, T. ., Đào Phương An, N. ., & Ngọc Tường Vi, Q. . (2022). EVALUATION OF RETICULOCYTE HEMOGLOBIN CONTENT VALUES IN DIAGNOSING IRON DEFICIENCY ANEMIA OF FIRST TRIMESTER PREGNANCY. Vietnam Medical Journal, 519(1). https://doi.org/10.51298/vmj.v519i1.3559

EVALUATION OF RETICULOCYTE HEMOGLOBIN CONTENT VALUES IN DIAGNOSING IRON DEFICIENCY ANEMIA OF FIRST TRIMESTER PREGNANCY

Phan Thị Cẩm Luyến1,, Hà Thị Anh2, Trần Quí Phương Linh3, Nguyễn Đào Phương An3, Quách Ngọc Tường Vi3
1 University of Medicine and Pharmacy at Ho Chi Minh City
2 Hong Bang International University
3 Le Van Thinh Hospital

Main Article Content

Abstract

Objects: Determining the value of reticulocyte hemoglobin content (Ret-He) in diagnosing iron deficiency anemia of pregnant women in the first trimester, establishing cut-off values ​​and evaluating specificity and sensitivity. This article studies the correlation between reticulocyte hemoglobin content and serum ferritin in iron deficiency anemia. Methods: Study of descriptive cross-sectional. Total 174 first-trimester pregnant women who visited Le Van Thinh Hospital from 12/2021 to 8/2022 were included in the study. Blood
samples collected from the subjects were submitted to a complete blood count and a serum ferritin test. Data were analyzed by comparing the groups with median and quartiles, analyzing Receiver Operating Characteristic (ROC) curves and Spearman correlation. Results: Iron deficiency anemia is defined as hemoglobin < 11g/dL and serum ferritin < 30mg/dL. Analyzing the Receiver Operating Characteristic (ROC) curve to calculate the area under the curve of 0.829, with a reticulocyte hemoglobin content cut-off of 31.3 mg/dL with a sensitivity of 82.1% and a specificity of 83.3%. There was a strong positive correlation between reticulocyte hemoglobin content and serum ferritin (r=0.652; p<0.001). Conclusion: The reticulocyte hemoglobin content is an early indicator of iron deficiency anemia in first trimester pregnancy. In addition, reticulocyte hemoglobin content can be a good predictor in assessing bone marrow iron storage.

Article Details

Keywords

Reticulocyte hemoglobin content, iron deficiency anemia, pregnant women

References

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