TĂNG TRIRELYCERIE MÁU RẤT NẶNG Ở BỆNH NHÂN VIÊM TỤY CẤP: YẾU TỐ NGUY CƠ VÀ KẾT CỤC LÂM SÀNG

Abstract

Objectives: The aims of this study were to assess the relationship between clinical factors, biochemical data and outcomes in patients with hypertriglyceride induced acute pancreatitis (HTGP) and the grades of hypertriglyceridemia (HTG) by Endocrine Society 2010. Methods: We retrospectively analyzed a total of 132 patients with HTGP from January 2017 to May 2019 at Cho Ray Hospital. HTGP patients were divided into two groups according to the grades of HTG by Endocrine Society: very severe HTG (³2000 mg/dL) and severe HTG (1000 – 1999 mg/dL). Serum TG levels measured within 48 hours of admission. We analyzed the differences between two groups of patients, including general infomation, clinical characteristics, biochemical data and outcomes. Results: Comparing with the severe HTG group, the mean of  hemoglobin (Hb) had significantly higher level in the very severe HTG group (p=0.017). There were significant differences in level of prothrombin time (PT) (p=0.001), creatinine (p=0.011) and the grade of creactive protein at 48 hours after admission (CRP₄₈) (p=0.019) between the two groups. The prevalence of history of dyslipidemia was significantly high in the very severe HTG group (p=0.022). Multivariate analysis demonstrated that history of dyslipidemia and level of CRP₄₈­­ were statistically significant relating with the very severe HTG (p<0.05). Conclusions: In patients with HTGP, there were significantly higher of Hb and lower of PT and creatinine in patients with the very severe HTG as compared to the severe HTG. According to the multivariate analysis, history of dyslipidemia and levels of CRP₄₈­­ were significant related to the very severe HTG (p<0.05).