TỔNG QUAN VỀ TÌNH HÌNH KHÁNG KHÁNG SINH CỦA MỘT SỐ VI KHUẨN THƯỜNG GÂY BỆNH TRÊN LÂM SÀNG TẠI VIỆT NAM TỪ 2017- 2022

Abstract

Antibiotic resistance has made empiric antibiotic selection more difficult, with higher failure rates. According to a study by Dinh Thi Thuy Ha in the treatment of multi-resistant gram-negative infections at Dong Nai General Hospital, the rate of initial antibiotic regimens being inappropriate was 35.8% and the majority of patients were changed. Treatment regimens immediately after the results of the antibiogram (64.9%) were obtained due to the condition not improving or the disease worsening [3]. The study was carried out with the objective: Overview of antibiotic resistance of some common pathogenic bacteria in Vietnam from 2017 to 2022. Research subjects and methods: Overview of data from the above articles Medical and Pharmaceutical journals, scientific conference reports, theses, theses, theses, international journal articles with reports on antibiotic resistance in Vietnam. Results: Streptococcus Pneumoniae has a high resistance rate, the MIC value exceeds the MIC resistance to penicillin G/V, amoxicillin, Macrolid, Sulfamide, Phenicol; Haemophilus influenza some antibiotics also have high sensitivity such as FQ, C3, Carbapenem; Klebsiella Pneumoniae in Nghe An and Thai Binh had ESBL birth rates of 14%, 15.8%, respectively; E.coli has a high rate of resistance to penicillin group (ampincilin, amoxicillin) tetracycline group, cephalosporins (C3 and C4), moderate resistance to FQ, and high sensitivity to Capabenem, Aminoside.  Pseudomonas aeruginosa still has a high rate of sensitivity to Colistin and piperacillin/tazobactam. Conclusion: Through the study, it can be seen that common pathogenic bacteria have a high clinical resistance rate, it is necessary to have data to determine the MIC value of antibiotics for each type of bacteria in order to adjust the dose according to PK/ PD to improve clinical effectiveness.