KẾT QUẢ HÓA XẠ TRỊ ĐỒNG THỜI PHÁC ĐỒ CISPLATIN – 5-FLUOROURACIL UNG THƯ BIỂU MÔ THỰC QUẢN GIAI ĐOẠN II, III TẠI BỆNH VIỆN K

Abstract

Purpose: Our study aims to assess the response to radical treatment of esophageal cancer stage II, III with concurrent chemoradiotherapy with the CISPLATIN – 5-FLUOROURACIL regimen and comment on some undesirable effects of the treatment regimen. Patients and method: A retrospective descriptive study on 40 patients with esophageal cancer stage II, III who were radically treated by chemoradiotherapy with CISPLATIN – 5-FLUOROURACIL regimen at Hospital K from/2020 to 08/2022. Results: Treatment results: All patients completed the first 2 cycles of concurrent chemoradiotherapy and the next 2 cycles of adjuvant CISPLATIN – 5-FLUOROURACIL. Evaluation of chest CT by RECIST showed that the response rate after 4 cycles of treatment reached 67.5%, of which complete response accounted for 37.5%, and partial response accounted for 30.0%. After 4 treatment cycles, 2 patients progressed (5.0%). Adverse events: mainly grade I toxicity, grade II, III toxicity accounts for a small proportion, no grade IV toxicity. Gastrointestinal toxicity is mainly vomiting and diarrhea. Most patients had radiation skin burns (90.0%) and esophagitis (60.0%) during treatment.