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OVERVIEW OF INDUCTION CHEMOTHERAPY IN ADVANCED HYPOPHARYNGEAL SQUAMOUS CELL CARCINOMA
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Abstract
Objectives: Analysis of response rates of induction chemotherapy and subsequent treatment directions. Study design: Scoping review. Methods: Using database from Pubmed website, Hanoi Medical University library and manual search (January 1996 to July 2022). The inclusion criteria were studies of advanced-stage hypopharyngeal squamous cell carcinoma treated with adjuvant chemotherapy followed by surgery/radiation/adjuvant chemoradiation and outcome reporting on incidence. complete response, partial response, retention rate (GN), progression rate (TTr) and cancer outcome at 3 years. Result: Outcomes at 3 years of prior induction chemotherapy. The complete response rate (CR) was 6-55.7%. The partial response rate (PR) is 32-80%. The no change (NC) ratio is 3.3-29.6%. The progressive disease rate (PD) was 6.7-7.5%. The rate of no distant metastasis was 75-91%. The overall survival rate (OS) and preserved larynx rate were achieved from 38.3-76.7% and 34-76, respectively. Conclusion: Induction chemotherapy helps in the treatment of patients with advanced stage of pharyngeal squamous cell carcinoma in reducing the rate of distant metastases, allowing the selection of patients for chemotherapy and radiotherapy, increasing the ability of organ preservation.
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Keywords
Advanced hypopharyngeal cancer, induction/adjuvant chemotherapy
References
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