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Date Published: 28/12/2022
Abstract Views: 249
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DOI: https://doi.org/10.51298/vmj.v520i1.3747
Issue
Vol. 520 No. 1A (2022)
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How to Cite
Thị Thiết, Đào ., & Thị Kiều My, T. . (2022). CHARACTERISTICS OF vWF FUNCTION TESTS IN PATIENTS WITH VON WILLEBRAND DISEASE AT NATIONAL INSTITUTE OF HEMATOLOGY AND BLOOD TRANSFUSION. Vietnam Medical Journal, 520(1A). https://doi.org/10.51298/vmj.v520i1.3747

CHARACTERISTICS OF vWF FUNCTION TESTS IN PATIENTS WITH VON WILLEBRAND DISEASE AT NATIONAL INSTITUTE OF HEMATOLOGY AND BLOOD TRANSFUSION

Đào Thị Thiết1,, Trần Thị Kiều My1,2
1 National Institute of Hematology and Blood Transfusion
2 Hanoi Medical University

Main Article Content

Abstract

Objective: To evaluate functions of von Willebrand factor in patients with hereditary von Willebrand disease in NIHBT. Method: This prospective study included 40 patients with hereditary vWD in NIHBT. Results: Both Collagen-binding activity and von Willebrand activity determined with HaemosIL reduced in all patients and the levels were highest in type 1 and lowest in type 3. vWF CB/Ag and vWF Act/Ag ratio of vWD type 2 were significantly lower compared to type 1 (p<0,001). All patients with vWD type 2 had low ratio of Act/Ag, 20% of them had normal CB/Ag ratio. Activities determined with HaemosIL correlated with collagen-binding (r2 = 0,774, p < 0.0001)

Article Details

Keywords

von Willebrand disease, von Willebrand Activity, Collagen binding

References

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