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Date Published: 28/12/2022
Abstract Views: 350
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DOI: https://doi.org/10.51298/vmj.v520i1.3750
Issue
Vol. 520 No. 1A (2022)
Section
Các bài báo
How to Cite
Thị Kiều My, T. ., Thị Hà, H. ., Hữu Trường, N. ., Thị Thiết, Đào ., & Quốc Khánh, B. . (2022). CHARACTERISTICS OF HAEMOSTATIC PARAMETERS IN PREGNANT SYSTEMIC LUPUS ERYTHEMATOSUS AT BACH MAI HOSPITAL. Vietnam Medical Journal, 520(1A). https://doi.org/10.51298/vmj.v520i1.3750

CHARACTERISTICS OF HAEMOSTATIC PARAMETERS IN PREGNANT SYSTEMIC LUPUS ERYTHEMATOSUS AT BACH MAI HOSPITAL

Trần Thị Kiều My1,2,, Hoàng Thị Hà3, Nguyễn Hữu Trường4, Đào Thị Thiết5, Bạch Quốc Khánh2
1 Hanoi Medical University
2 National Institute of Hematology and Blood Transfusion
3 Ha Nam Hospital for Women and Children
4 Bach Mai Hospital
5 Viện Huyết học - Truyền Máu Trung ương

Main Article Content

Abstract

Objectives: Systemic lupus erythematosus (SLE) is considered a hypercoagulable condition. So, SLE pregnancies have a higher risk of thrombosis than healthy pregnancies. Therefore, this study aims to observe the change of some hemostatic markers in SLE pregnancies compared to healthy pregnancies. Subjects and methods: a prospective, cross-sectional descriptive study including 103 SLE pregnancies and 30 healthy pregnancies as a control group. Hemostatic parameters performed include PT, APTT, fibrinogen, D dimer (DD), Fibrin monomer (FM) concentrations and platelet. Results: PT, APTT, fibrinogen concentrations and platelet were similar in the two groups. In SLE pregnancies, the mean concentrations of DD and FM were 1.584 ± 1.341 mg/L and 16.56 ± 35.57 mg/L, were significantly higher than normal pregnancies (p = 0.015, p = 0.001, respectively), especially middle and late pregnancy. The percentage of elevated DD concentrations (> 0.5 mg/L) was 83.5%, similar in healthy pregnancies (p = 0,210). The percentage of increased FM concentrations (> 6.0 mg/L) was 28.2% but the healthy pregnancies were not (p = 0.001). DD and FM concentrations were moderately correlated (r2 = 0.20; p < 0.001) while in healthy pregnancies, they were not correlated (p = 0.244). Conclusions: The baseline hemostatic parameters indices and D dimer had kinetic changes with gestational age, but there was no difference between lupus and healthy pregnant women. Elevated FM values in pregnant women with lupus suggest an increased risk of thrombosis and should be used for patient monitoring.

Article Details

Keywords

coagulation, thrombotic, SLE pregnancy

References

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