Article Sidebar

PDF
Date Published: 28/12/2022
Abstract Views: 304
Views PDF: 140
DOI: https://doi.org/10.51298/vmj.v520i1.3767
Issue
Vol. 520 No. 1A (2022)
Section
Các bài báo
How to Cite
Mạnh Tường, N. ., & Bích Nga, V. . (2022). SURVEYING SERUM NT-PROBNP CONCENTRATION IN NEWLY DIAGNOSED BASEDOW’ PATIENTS AT HANOI MEDICAL UNIVERSITY HOSPITAL. Vietnam Medical Journal, 520(1A). https://doi.org/10.51298/vmj.v520i1.3767

SURVEYING SERUM NT-PROBNP CONCENTRATION IN NEWLY DIAGNOSED BASEDOW’ PATIENTS AT HANOI MEDICAL UNIVERSITY HOSPITAL

Nguyễn Mạnh Tường1, Vũ Bích Nga1
1 Hanoi Medical University

Main Article Content

Abstract

Research objectives: 1. To survey serum NT-proBNP concentration in newly diagnosed Basedow’s patients at Hanoi Medical University Hospital. 2. To determinethe some factors related to serum NT-proBNP concentration in newly diagnosed Basedow’s patients. Research subjects: 97 patients newly diagnosed with Basedow’s disease for the first time at Hanoi Medical University Hospital from October 2021 to September 2022, were tested for serum NT-proBNP and assessed by Doppler echocardiography some morphological and functional indices. Method: Cross-sectional description. Results: Mean age: 38.55 ± 12.84, female/male ratio: 3.4/1. The concentration of NT-proBNP in female patients is higher than in male patients, the increase in NT-proBNP is proportional to blood FT4 and TrAb levels, left atrial diameter and systolic pulmonary artery pressure (SBP), the difference is Statistical significance with p < 0.05. Conclusion: The concentration of NT-proBNP was significantly related to sex, FT4, serum TrAb and some morphological and cardiac function indices on ultrasound in newly diagnosed Basedow’s patients.

Article Details

Keywords

Basedow’s disease, newly diagnosed, serum NT-proBNP concentration, echocardiography

References

1. Kha, T. T., & Vinh, H. T. (2022). LIÊN QUAN GIỮA NỒNG ĐỘ NT-proBNP HUYẾT THANH VỚI MỘT SỐ THÔNG SỐ SIÊU ÂM TIM Ở BỆNH NHÂN BASEDOW NHIỄM ĐỘC HORMON TUYẾN GIÁP. Tạp chí Y học Việt Nam, 515(2).
2. Nguyễn Quang Bảy (2020), Chẩn đoán và điều trị cường giáp. Hà Nội, Nhà xuất bản Y học, pp. 100-101.
3. Bodlaj, G., Pichler, R., Brandstätter, W., Hatzl‐Griesenhofer, M., Maschek, W., Biesenbach, G., & Berg, J. (2007). Hyperthyroidism affects arterial stiffness, plasma NT‐pro‐B‐type natriuretic peptide levels, and subendocardial perfusion in patients with Graves' disease. Annals of medicine, 39(8), 608-616.
4. Gu, L. Q., Zhao, L., Zhu, W., Li, F. Y., Zhang, M. J., Liu, Y., ... & Zhao, Y. J. (2011). Relationships between serum levels of thyroid hormones and serum concentrations of asymmetric dimethylarginine (ADMA) and N-terminal-pro-B-type natriuretic peptide (NT-proBNP) in patients with Graves’ disease. Endocrine, 39(3), 266-271.
5. G. J. Kahaly, L. Bartalena, L. Hegedüs, L. Leenhardt, K. Poppe, S. H. Pearce (2018), 2018 European Thyroid Association Guideline for the Management of Graves' Hyperthyroidism. European thyroid journal.7(4):167-186.
6. Keiko Kato, Hitomi Murakami, Osamu Isozaki, et al. (2009), “Serum Concentrations of BNP and ANP in patients with Thyrotoxicosis”, Endocrine Journal, 56(1), pp. 17-27.
7. Masakazu Kohno, Takeshi Horia, Kenichi Yasunari et al. (1993), “Stimulation of Brain Natriuretic Peptide Release from the Heart by Thyroid Hormone”, Matabolism, 42(8), pp. 1059-1064.
8. McDonagh TA, Metra M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC). With the special contribution of the Heart Failure Association (HFA) of the ESC. European J of Heart Fail. 2022;24(1):4-131. doi:10.1002/ejhf.2333
9. Joyce Man, Phil Barnett, Vincent M. Christoffels (2017), “Structure and function of the Nppa-Nppb cluster locus during heart development and disease”, Cellular and Molecular Life Sciences, doi:10.007/s00018-017-2737-0.
10. Richard W. Troughton, A. Mark Richards (2009), “B-Type Natriuretic Peptides and Enchocardiographic Measures of Cardiac Structure and Function”, Cardiovascular Imaging, 2(2), pp. 216-225.