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Date Published: 12/06/2021
Abstract Views: 174
Views PDF: 135
DOI: https://doi.org/10.51298/vmj.v500i2.377
Issue
Vol. 500 No. 2 (2021)
Section
Các bài báo
How to Cite
Thanh Thúy, N. ., & Ngọc Anh, L. . (2021). RELATIONSHIP BETWEEN MATERNAL KIR2DL5 AND KIR2DS4 GENES WITH PREECLAMPSIA. Vietnam Medical Journal, 500(2). https://doi.org/10.51298/vmj.v500i2.377

RELATIONSHIP BETWEEN MATERNAL KIR2DL5 AND KIR2DS4 GENES WITH PREECLAMPSIA

Nguyễn Thanh Thúy, Lê Ngọc Anh

Main Article Content

Abstract

The pathogenesis of preeclampsia may involve inadequate trophoblast invasion caused by excessive inhibition of decidual natural killer cells (dNK) by extravillous trophoblast cells. Fetomaternal immune tolerance induced by dNK is a necessary phenomenon associated with maternal killer-cell immunoglobulin-like receptors (KIRs) and fetal human leukocyte antigens (HLAs). Objectives: To determine the frequency of two maternal KIR genes KIR2DL5, KIR2DS4 and investigate whether certain combinations with some preeclampsia symptoms.  Subjects and methods: A case-control study was conducted in 100 pregnant women with preeclampsia and 100 normal pregnant women. DNA samples were assayed through polymerase chain reaction with sequence-specific primers (PCR - SSP). Results and conclusion: The frequency of the KIR2DL5 gene and KIR2DL5+ KIR2DS4+ genotype was decreased in the preeclampsia group compared with controls (p < 0.05). In the preeclampsia group, the presence of the KIR2DS4 gene made the weight of new-borns decrease (p<0.05), and the quantity of erythrocyte was higher in the KIR2DL5+ KIR2DS4+ group than in the KIR2DL5-KIR2DS4+ group (p<0,05).

Article Details

Keywords

Preeclampsia, KIR, KIR2DL5 gene, KIR2DS4 gene

References

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