ĐẶC ĐIỂM LÂM SÀNG CỦA PHỔ BỆNH VIÊM TỦY THỊ THẦN KINH

Abstract

Objective: To describe the clinical features of neuromyelitis optica spectrum disorder (NMOSD). Subjects and methods: We studied 42 patients who were treated at the Neurology Center of Bach Mai hospital and were diagnosed with NMOSD. Results: The disease mainly affects women (80.1%), female/male ratio of 4:1. Mean age of onset was 36.3 ± 12.1. The comorbidities with other autoimmune diseases are 15.2%. There were 90.5% of patients relapsed. Common symptoms are a loss of bilateral visual acuity 45.2%, motor paralysis and sensory disturbances 90.5%, urination disorder 66.7%, in addition, other symptoms are less common such as involuntary muscle contractions 19%, cerebellar damage 14.2%, cranial nerve palsy 19%, vomiting, hiccups 23.8%. Patients were diagnosed with NMOSD based on anti-aquaporin 4 antibody test with acute myelitis and optic neuritis 83.3%, Postrema area 11.9%, brain stem/cerebellar syndrome 14.3%, simple optic neuritis 4.8%, diencephalic lesions 4.8%. Conclusion: Clinical symptoms correspond to acute spinal cord injury, and optic neuritis, in addition, there are lesions in the brainstem, diencephalic and cerebral hemispheres.