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Date Published: 28/12/2022
Abstract Views: 698
Views PDF: 188
DOI: https://doi.org/10.51298/vmj.v520i1A.3808
Issue
Vol. 520 No. 1A (2022)
Section
Các bài báo
How to Cite
Thị Hồng Liễu, P. ., Tiến Dũng, Đỗ, & Thị Thu Hà, N. . (2022). VALUE OF SOME BLOOD CELL INDICATORS ON THE DXH 900 HEMATOLOGY ANALYZER IN DETECTING BACTEREMIA AT VIETNAM NATIONAL CANCER HOSPITAL IN 2022. Vietnam Medical Journal, 520(1A). https://doi.org/10.51298/vmj.v520i1A.3808

VALUE OF SOME BLOOD CELL INDICATORS ON THE DXH 900 HEMATOLOGY ANALYZER IN DETECTING BACTEREMIA AT VIETNAM NATIONAL CANCER HOSPITAL IN 2022

Phạm Thị Hồng Liễu1,, Đỗ Tiến Dũng2, Nguyễn Thị Thu Hà3
1 Vietnam National Cancer Hospital
2 National Hospital of Endocrinology
3 Hanoi University of Public Health

Main Article Content

Abstract

Introductions: Sepsis is a serious systemic bacterial infection. It occurs in every country in the world, especially in tropical countries, like Vietnam. The diagnosis of sepsis remains challenges due to the confusing symptoms. The MDW is a new indicator on Backman Coulter's DxH 900 hematology analyser, which has been studied as a diagnostic marker for early sepsis detection. Objectives: 1. Determination of changes in some peripheral blood indexes in patients with sepsis. 2. Analysis of the significance of MDW index in patients with sepsis at the Emergency and Intensive Care Unit of National Cancer Hospital in 2022. Patients and methods: The study was carried out at the Emergency and Intensive Care Unit of Cancer-Tan Trieu Hospital from January 2022 to August 2022. A total of 264 patients were divided into 3 groups as follows: 67 ones with sepsis, 83 ones with infection and 114 ones non-infection. All patients were tested for peripheral blood cell count within the first 24 hours after admission. Results: The analysis results showed that there was a difference in peripheral blood indexes such as hemoglobin, neutrophil, monocytes and MDW (monocyte distribution width) among the study groups, p<0.05. The MDW value of each group of sepsis, infection and non infection was 28.19 (24.2-33.9), 24.0 (22.1-28.7) and 19.5(18.0-20.6) respectively, p<0.05. Analysis of the ROC curve showed that the MDW index achieved the best value at the cut off = 22.0 with Se=0.96, Sp=0.93, AUC=0.98. Conclusions: MDW=22.0 index is valid in diagnosing sepsis with Se=0.96, Sp=0.93, AUC=0.98, p<0.05.

Article Details

Keywords

MDW, sepsis

References

1. Nguyễn Quốc Anh and Ngô Quý Châu (2012). Nhiễm khuẩn huyết , hướng dẫn chuẩn đoán và điều trị bệnh nội khoa. Nhà xuất bản Y học, Hà Nội.
2. Levy M, et al (2003). International Sepsis Definitions Conference, SCCM/ESICM/ACCP/ ATS/ SIS International Sepsis Definitions Conference ….
3. Garme JS, et al (1996). CDC definitions for nosocomial infections. In: Olmsted RN, ed.: APIC Infection Control and Applied Epidemiology: Principles and Practice. St. Louis: Mosby. p. 1-20.
4. Organization W.H (2011). Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. World Health Organization.
5. Khương Thị Thanh Tâm (2017). Nghiên cứu một số đặc điểm tế bào máu ngoại vi của bệnh nhân nhiểm khuẩn huyết tại bệnh viện Đại học Y Hà Nội 2013-2017. Đại học Y Hà Nội.
6. Kaser A, et al (2001). Interleukin-6 stimulates thrombopoiesis through thrombopoietin: role in inflammatory thrombocytosis. 98(9): p. 2720-2725.
7. Oh D.-K, C.J. Park, and S.-B. Hong (2020). Monocyte Distribution Widths for Early Sepsis Detection in Emergency Department and Comparison with C-reactive Protein and Procalcitonin.
8. Polilli E, et al (2020). Comparison of Monocyte Distribution Width (MDW) and Procalcitonin for early recognition of sepsis. 15(1): p. e0227300.
9. Kim M, et al (2004). Cl–channels are expressed in human normal monocytes: a functional role in migration, adhesion and volume change. 2004. 138(3): p. 453-459.