Article Sidebar

PDF
Date Published: 28/12/2022
Abstract Views: 174
Views PDF: 129
DOI: https://doi.org/10.51298/vmj.v520i1A.3813
Issue
Vol. 520 No. 1A (2022)
Section
Các bài báo
How to Cite
Việt Khải, N. ., Đức Trung, N. ., Quang Nghĩa, N. ., & Tiến Quyết, N. . (2022). THE OUTCOME OF LIVER TRANSPLANTATION FOR HEPATOCELLULAR CARCINOMA BEYOND MILAN CRITERIA AT VIETDUC UNIVERSITY HOSPITAL. Vietnam Medical Journal, 520(1A). https://doi.org/10.51298/vmj.v520i1A.3813

THE OUTCOME OF LIVER TRANSPLANTATION FOR HEPATOCELLULAR CARCINOMA BEYOND MILAN CRITERIA AT VIETDUC UNIVERSITY HOSPITAL

Ninh Việt Khải1,, Nguyễn Đức Trung2, Nguyễn Quang Nghĩa1, Nguyễn Tiến Quyết1
1 Organ Transplant Centre, Vietduc University Hospital
2 Surgical resident at Hanoi Medical University

Main Article Content

Abstract

Objectives: Evaluating the outcome of liver transplantation for hepatocellular carcinoma beyond Milan criteria at VietDuc University hospital. Subject and methods: The retrospective sstudy of 33 patients with hepatocellular carcincarcinoma (HCC) beyond Milan criteria performed liver transplantation at VietDuc University hospital from 5/2012 – 5/2022. Result: Average age 55,06 ± 8,3, hepatitis B virus infection 87,6%, pre-liver transplant adjuvant treatment with TACE or and 84,8%, pre - liver transplant alpha fetoprotein (AFP) > 200 ng/ml 21,2%. Child A 69,7%, beyond Milan criteria but in University of California San Fransico (UCFS) criteria 33,3%, beyond UCSF 66,7%. Living donor liver transplantation 12,1%, brain death donor liver transplantation 87,9%, cold ischemic time 163,8 ± 82,2 minutes, warm ischemic time 53,2 ± 14,4 minutes. Hepatic thrombosis and portal vein thrombosis 3%, postransplanted bleeding 6,1%, postransplanted mortality 6,1%. The overall survival at 1 - year, 3 - year and 5 - year is 75,6%, 72,5 % and 72,5%. The disease - free survival at 1 – year, 3 – year and 5 – year 77,4%, 73,7& and 70%. Conclusion: Liver transplantation is a effective treatment for hepatacellular carcinoma even beyond Milan criteria.

Article Details

Keywords

ghép gan, ung thư biểu mô tế bào gan

References

1. Kulik, L. and H.B. El-Serag, Epidemiology and Management of Hepatocellular Carcinoma. Gastroenterology, 2019. 156(2): p. 477-491 e1.
2. Mazzaferro, V., et al., Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med, 1996. 334(11): p. 693-9.
3. Yao, F.Y., et al., Liver transplantation for hepatocellular carcinoma: expansion of the tumor size limits does not adversely impact survival. Hepatology, 2001. 33(6): p. 1394-403.
4. Mazzaferro, V., et al., Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis. Lancet Oncol, 2009. 10(1): p. 35-43.
5. Majno, P.E., et al., Influence of preoperative transarterial lipiodol chemoembolization on resection and transplantation for hepatocellular carcinoma in patients with cirrhosis. Ann Surg, 1997. 226(6): p. 688-701; discussion 701-3.
6. Yao, F.Y., et al., Excellent outcome following down-staging of hepatocellular carcinoma prior to liver transplantation: an intention-to-treat analysis. Hepatology, 2008. 48(3): p. 819-27.
7. Sugawara, Y., S. Tamura, and M. Makuuchi, Living donor liver transplantation for hepatocellular carcinoma: Tokyo University series. Dig Dis, 2007. 25(4): p. 310-2.
8. Lee, S.G., et al., Expanded indication criteria of living donor liver transplantation for hepatocellular carcinoma at one large-volume center. Liver Transpl, 2008. 14(7): p. 935-45.
9. Takada, Y., et al., Living donor liver transplantation for patients with HCC exceeding the Milan criteria: a proposal of expanded criteria. Dig Dis, 2007. 25(4): p. 299-302.
10. Broelsch, C.E., A. Frilling, and M. Malago, Should we expand the criteria for liver transplantation for hepatocellular carcinoma--yes, of course! J Hepatol, 2005. 43(4): p. 569-73.