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EVALUATE ACUTE TOXICITY AND SEMI-PERMANENT TOXICITY OF SHEN CAO GAN JIANG TANG (SAM THAO CAN KHUONG THANG)
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Abstract
Objectives: To study the acute toxicity and semi-permanent toxicity of Shen Cao Gan Jiang Tang (SCGJT) in experimental animals. Subjects and methods: The study was conducted on Swiss albino white mice. Acute toxicity and semi-permanent toxicity of SCGJT were evaluated according to the guidance of the Ministry of Health. Results: The acute toxicity and LD50 of SCGJT in maximum dose of 200 ml/kg cannot be determined. The mice weight, hematopoietic function, liver and kidney function, and other organisms were generally unaffected when using SCGJT with the dose of 4 and 12 ml/kg during 14 and 28 days. Conclusion: SCGJT has no acute and semi-permanent toxicity in experimental mice. However, caution should be excercised regarding the potential for decreasing the number of platelets in male mices.
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Keywords
Shen Cao Gan Jiang Tang, acute toxicity, semi-permanent toxicity
References
2. Bộ Y tế, Hướng dẫn thử nghiệm tiền lâm sàng và lâm sàng thuốc đông y, thuốc từ dược liệu, Quyết định số 141, ngày 27 tháng 10 năm 2015.
3. Đỗ Trung Đàm, Phương pháp xác định độc tính cấp của thuốc, Nhà xuất bản Y học, Hà Nội, 2014.
4. Trương Trọng Cảnh, Thương hàn luận, Nhà xuất bản Đồng Nai, 1996.
5. Brunt E. M., Grading and staging the histopathological lesions of chronic hepatitis: the Knodell histology activity index and beyond, Hepatology, 2000;31(1):241-246.
6. Laurie M. Serfilippi, Danielle R. Stackhouse Pallman, Bonita Russel, Charles B. Spainhour, Serum clinical chemistry and hematology reference value on outbred stocks of Albino mice from three commonly used vendors and two inbred strains of Albino mice, Contemporary Topics by The American Association for Laboratory Animal Science, 2003;42(3):46-52.