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CHARACTERIZATION AND DRUG RELEASE STUDY ON MOUSE SKIN OF METHYL SALICYLATE MICROEMULSION
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Abstract
This study aims to characterize microemulsion loaded with methyl salicylate 5% for particles size and distribution, refractive index, morphology and released drug through the mouse skin. The results showed that the microemulsion has transparent, colorless appearance, the particles size were about 20 nm, the PDI was less than 0.2. The refractive index of methyl salicylate microemulsion ranged from 1.415 to 1.428. Percentage of released methyl salicylate through the mouse skin from A1 and A1’ microemulsions increased rapidly in the first 6 hours and were higher than methyl salicylate ointment by 1.3 times. Methyl salicylate microemulsion is potential transdermal drug delivery system for use in acute pain relief.
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Keywords
microemulsion, methyl salicylate, transdermal drug delivery
References
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