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Date Published: 10/02/2023
Abstract Views: 327
Views PDF: 176
DOI: https://doi.org/10.51298/vmj.v520i1B.3914
Issue
Vol. 520 No. 1B (2022)
Section
Các bài báo
How to Cite
Nguyễn, . T. M. L., Hoàng , A. V., Dương , B. T., & Phùng , N. T. N. (2023). PREVALENCE OF NUDT15 VARIANTS IN ACUTE LYPHOBLASTIC LEUKEMIA AT CHILDREN’S HOSPITAL 2. Vietnam Medical Journal, 520(1B). https://doi.org/10.51298/vmj.v520i1B.3914

PREVALENCE OF NUDT15 VARIANTS IN ACUTE LYPHOBLASTIC LEUKEMIA AT CHILDREN’S HOSPITAL 2

Thị Mai Lan Nguyễn1,2,, Anh Vũ Hoàng 2,3, Bích Trâm Dương 2,3, Nguyễn Thế Nguyên Phùng 2,4
1 Children's Hospital 2
2 University of Medicine and Pharmacy at Ho Chi Minh City
3 Center For Molecular Biomedicine, University of Medicine and Pharmacy at Ho Chi Minh City
4 Children's Hospital 1, University of Medicine and Pharmacy at Ho Chi Minh City

Main Article Content

Abstract

Objects: The nucleoside diphosphate-linked moiety X-type motif 15 genes were high frequency of NUDT15 variants in Asian and affected the metabolism of 6-mercaptopurine, a prolonged backbone of acute lymphoblastic leukemia treatment (ALL). The patients with NUDT15 variants failured in 6-MP metabolism, leading to increased mortality risk. Aims: This study reports the frequency of NUDT15 variants in children with ALL at Children’s Hospital 2. Methods: A total of 220 patients with ALL were identified NUDT15 variants on exon 1 and exon 3 in chromosome 13 by Sanger sequencing. Results: We identified five variants of NUDT15, including *1, *2, *3, *5, *6 (87%; 2,7%; 6,9%; 0,9% và 2,5%; respectively). We didn’t identify *4 in our study. The NUDT15 genotyping showed 25% of patients with NUDT15 variants: heterozygous (24.1%) and homozygous/compound heterozygous (0.9%). Conclusion: NUDT15 variants were presented in one-fourth of the participants. To the personalized medicine of 6-MP, testing for NUDT15 polymorphisms prior to therapy is warranted.

Article Details

Keywords

NUDT15, variant, 6-mercaptopurine, acute lymphoblastic leukemia

References

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