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Date Published: 10/02/2023
Abstract Views: 558
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DOI: https://doi.org/10.51298/vmj.v520i1B.3915
Issue
Vol. 520 No. 1B (2022)
Section
Các bài báo
How to Cite
Nguyễn , V. H., Trần , T. N., Lê , V. H., Ngọ , T. U., Nguyễn , K. Đồng, & Nguyễn , H. V. (2023). EPSTEIN-BARR VIRUS AND HUMAN PAPILLOMAVIRUS CO-PRESENCE IN NASOPHARYNGEAL NON-KERATINIZING SQUAMOUS CELL CARCINOMA. Vietnam Medical Journal, 520(1B). https://doi.org/10.51298/vmj.v520i1B.3915

EPSTEIN-BARR VIRUS AND HUMAN PAPILLOMAVIRUS CO-PRESENCE IN NASOPHARYNGEAL NON-KERATINIZING SQUAMOUS CELL CARCINOMA

Văn Hùng Nguyễn 1, Tín Nghĩa Trần 2,3, Văn Hưng Lê 3, Thị Uyên Ngọ 3, Kim Đồng Nguyễn 3, Hoàng Việt Nguyễn 3,
1 Hanoi Medical University Hospital
2 Can Tho University of Medicine and Pharmacy
3 Hanoi Medical University

Main Article Content

Abstract

Objectives: Evaluated the association between EBV & HPV co-infection in nasopharyngeal non-keratinizing squamous cell carcinoma. Subjects and methods: We designed a cross-sectional study, that was realized on 95 FFPE samples from nasopharyngeal non-keratinizing squamous cell carcinoma, were collected at Hanoi Medical University Hospital from 1/2021 to 6/2022. Results: the average age of nasopharyngeal carcinoma patients is 52,75 (16-87), and the incidence rate of NPC was greater in men than women. In the association between EBV&HPV, the results showed that the rate of EBV infection was 95.8%, and the rate of HPV infection was 15,8% (mainly HPV16 (86,7%)). However, the rate of EBV/HPV co-infection was 13,7%, the rate of only EBV infection was 82,1%, only HPV was 2,1% and 2,1% of patients were not infected with both viruses. Our results showed EBV and HPV co-presence in nasopharyngeal non-keratinizing squamous cell carcinoma, especially including high-risk HPV types. Results suggested that HPV may be co-factor with high risk factor is EBV will be increased NPC progression.

Article Details

Keywords

nasopharyngealcarcinoma, Epstein-Barr virus, Human Papillomavirus

References

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