EVALUATION CHARACTERISTICS OF LAMINA CRIBROSA IN OPEN-ANGLE GLAUCOMA USING ENHANCED DEPTH IMAGING OCT

Thanh Huyền Phạm1,, Thị Vân Anh Bùi2, Vân Anh Cát2, Thị Ngọc Bích Phạm 1
1 Hanoi Medical University
2 National Institute of Ophthalmology

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Abstract

Objectives: To evaluate the characteristics of the lamina cribrosa in patients with open-angle glaucoma by Enhanced Depth Imaging Optical Coherence Tomography and learn some related factors. Subjects and methods: Cross-sectional descriptive study, continuous sampling during the study period. All cases of open-angle glaucoma patients with confirmed diagnosis came to the National Eye Hospital from August 2020 to June 2021. Results: The study was conducted on 2 groups of subjects, the first group of 25 patients with 42 open-angle glaucoma eyes, the second group of 11 people with 22 normal eyes. The average lamina cribrosa thickness in the glaucoma group was 153.94 ± 46.85µm. The average lamina cribrosa depth is 537.50 ± 183.56 µm. The thickness prelamina tissue is 171.54 ± 77.46 µm. Focal lesions of the lamina cribrosa were encountered with a rate of 42.82%. The most common localized lesions are inferior and superior, there are no temporal or nasal lesions. The lamina cribrosa becomes thinner as the disease stage is more severe. Lamina cribrosa depth increased at the early stages of the disease (p = 0.002). The more severe the disease stage, the greater the number of lamina cribrosa’s localized lesions. (p<0.001). Conclusion: Patients with open-angle glaucoma have decrease laminar cribrosa thickness, increase laminar cribrosa depth and more focal lesions on the lamina cribrosa than normal people. The more advanced the disease, the thinner the lamina cribrosa thickness, the greater the leaf depth and the greater the number of lesions located on the lamina cribrosa.

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References

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