HIỆU QUẢ ĐIỀU TRỊ VIÊM TỤY CẤP DO TĂNG TRIGLYCERIDEMÁU BẰNG BIỆN PHÁP THAY THẾ HUYẾT TƯƠNG VỚI DUNG DỊCH ALBUMIN 5% TẠI BỆNH VIỆN BẠCH MAI

Abstract

The study was conducted to evaluate the effectiveness of plasma replacement therapy with 5% albumin solution in patients with acute pancreatitis due to hypertriglyceridemia. An intervention study comparing before and after without a control group evaluated the change of clinical and subclinical symptoms on 37 patients before and after the interventions from August 2021 to July 2022. Results: The triglyceride index decreased from 113.1 ± 200.8 mmol/l upon admission to 13.76 ± 11.64 mmol/l after the intervention. Functional symptoms such as abdominal pain, nausea, vomiting, bowel obstruction, abdominal distension and physical symptoms include: dorsal flank score, abdominal wall reaction, ascites, decreased peritoneal sensation after treatment. The proportion of patients with APACHE II score 8 points decreased from 27.03% on admission to 17.14% after the 2nd PEX (p<0.05) and the SOFA score 2 points decreased from 64.9% to 35.1% after intervention (p<0.05). From these results, the study shows that plasma replacement with 5% albumin solution is effective in treating patients with acute pancreatitis due to hypertriglyceridemia.