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Date Published: 12/06/2021
Abstract Views: 165
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DOI: https://doi.org/10.51298/vmj.v500i2.398
Issue
Vol. 500 No. 2 (2021)
Section
Các bài báo
How to Cite
Thành Chung, Đặng ., Thu Hằng, N. ., Khắc Cường, B. ., & Văn Mão, C. . (2021). EVALUATING THE SIDE EFFECTS OF CAR-T CELLS ON EXPERIMENTAL ANIMALS. Vietnam Medical Journal, 500(2). https://doi.org/10.51298/vmj.v500i2.398

EVALUATING THE SIDE EFFECTS OF CAR-T CELLS ON EXPERIMENTAL ANIMALS

Đặng Thành Chung, Ngô Thu Hằng, Bùi Khắc Cường, Cấn Văn Mão

Main Article Content

Abstract

Objectives: This study aims to evaluate of side effects of CAR-T cells on experimental animals. Methods: Mice are injected a single doses of 5x105, 106 and 5x106 CAR-T cell in the study group and 106 PBMC cell into the peritoneal cavity. Animals were weighed and given health assessments every day. Evaluating the hematopoietic function, liver function, kidney function and change the concentration of cytokines IL2, IL6, TNF-α in mouse serum by ELISA technique. Results: Weight, hematopoietic function, liver function, kidney function and concentrations of cytokines IL2, IL6, and TNF-α in all 3 groups injected CAR-T at doses differences had no significant difference compared to the control group (p> 0.05). Conclusion: CAR-T did not cause side effects in experimental animals 4 weeks after treatment.

Article Details

Keywords

CAR-T cell, side effects, cytokines

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