RESEARCH CHARACTERISTICS OF CLINICAL, PARACLINICAL PERIPHERAL NERVE DAMAGE IN NEWLY DIAGNOSED TYPE 2 DIABETES PATIENTS

Thị Anh Nguyễn1,, Văn Tuận Nguyễn2,3, Quang Bảy Nguyễn1
1 Hanoi Medical University
2 Bach Mai Hospital
3 VNU Hanoi-University of Medicine and Pharmacy

Main Article Content

Abstract

Objectives: To describe the clinical and electrophysiological characteristics of peripheral nerve damage in newly diagnosed type 2 diabetes patients. Subjects and methods: A cross-sectional descriptive study was conducted on 98 people with newly diagnosed type 2 diabetes patients at the Department of Endocrinology - Diabetes and Neurology Center of Bach Mai Hospital. Results: The mean age of the study group was 58.05 ± 12.82. The most common group is over 60 years old 45.9%, male/female ratio is 1.45. The proportion of patients with comorbid hypertension was 65.3%, dyslipidemia was 71.4%. At the time of diagnosis of Diabetes, the majority of patients had a high HbA1C level over 7%, accounting for 86.7%, with an average HbA1C level of 11.8%. Decrease/ loss of Achilles tendon reflex is a common clinical sign, suggesting nerve damage in people with diabetes. There were 22 patients with changes in nerve conduction measurements. In which, reduction of motor amplitude and prolongation of sensory conduction velocity are the most common. Conclusions: Nerve conduction measurement can reveal early changes in peripheral nerve damage in patients with newly diagnosed diabetes.

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References

1. Pop-Busui R, Boulton AJM, Feldman EL, et al. Diabetic Neuropathy: A Position Statement by the American Diabetes Association. Diabetes Care. 2017;40(1):136-154.
2. Camacho PM, Petak SM, Binkley N, et al. American Association of Clinical Endocrinologists/ American College of Endocrinology Clinical Practice Guidelines for the diagnosis and treatment of postmenopausal osteoporosis -2020 Update. Endocr Pract Off J Am Coll Endocrinol Am Assoc Clin Endocrinol. 2020.
3. Tôn Thất Kha. Nghiên cứu bệnh nhiều dây thần kinh ở bệnh nhân ĐTĐ týp 2 bằng điện sinh lý thần kinh ngoại vi. Luận văn thạc sĩ y học. Trường đại học Y Hà Nội 2011.
4. Trần Thị Nhật. Nghiên cứu tỷ lệ biến chứng thần kinh ngoại vi ở bệnh nhân ĐTĐ tại khoa khám bệnh Bệnh viện Bạch Mai. Luận văn Thạc sĩ y học, Đại học Y Hà Nội 2010.
5. Gill HK, Yadav SB, Ramesh V, Bhatia E. A prospective study of prevalence and association of peripheral neuropathy in Indian patients with newly diagnosed type 2 diabetes mellitus. J Postgrad Med. 2014;60(3):270-275.
6. Dương Thị Thu Phương. Bước đầu ứng dụng bộ dụng cụ Milgamma trong chẩn đoán và phân loại biến chứng viêm đa dây thần kinh ngoại biên trên bệnh nhân Đái Tháo Đường. Luận văn Thạc sĩ y học, Đại học Y Hà Nội 2012.
7. De Souza RJ, de Souza A, Nagvekar MD. Nerve conduction studies in diabetics presymptomatic and symptomatic for diabetic polyneuropathy. J Diabetes Complications. 2015;29(6):811-817.