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PLASMA D-DIMER CONCENTRATION IN PATIENTS WITH ACUTE ISCHEMIC STROKE AT PHU YEN GENERAL HOSPITAL
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Abstract
Introduction: D-dimer, the final product of plasma in-mediated degradation of fibrin-rich thrombi, has emerged as a simple blood test that can be used in diagnostic algorithms for the exclusion of venous thromboembolism. D-dimer levels have certain advantages over other measures of thrombin generation, because it is resistant to ex vivo activation, relatively stable, and has a long half-life. Acute ischemic stroke (AIS) is one of the major causes of death worldwide. D-dimer can be seen as an outcome predictor in ischemic stroke and an indicator of the severity stroke. Objective: This study aims to determine the level of D-dimer in patients with AIS and analyse some related factors. Materials and method: A cross-sectional descriptive study, comparison with a control group. We measured plasma levels of D-dimer in 51 patients ≥ 18 years of age who were diagnosed with acute ischemic stroke at Phu Yen General Hospital from October 2021 to August 2022. In the control group, we randomly selected 30 patients with being treated at Phu Yen General Hospital. D-dimer test is performed immediately upon admission and 48h after stroke onset using Coapresta 2000. Result: The mean ± SD titers of the D-dimer test in patients with AIS were higher than in the control group (1338,4 ± 895,2 vs 335,8 ± 216,1 ng/ml), which were statistically meaningful (p < 0,05). Based on the Receiver operating characteristic (ROC) curve, the optimal cut-off value of plasma D-dimer levels as an indicator for diagnosis of AIS was projected to be 764 ng/ml, which yielded a sensitivity of 72,5% and a specificity of 66,7%, the area under the curve was 0.919. There was a significant positive correlation between D-dimer levels with the duration of the National Institutes of Health Stroke Scale (NIHSS) score and infarct volume. Conclusion: We had shown that plasma D-dimer levels increased with increasing severity of stroke as defined by the NIHSS score and infarct volume.
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Keywords
plasma D-dimer level, acute ischemic stroke
References
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