ASSESSMENT OF TREATMENT RESULTS FOR METASTATIC DIFFERENTIATED THYROID CANCER AFTER SURGERY WITH I-131 AT NGHE AN ONCOLOGY HOSPITAL

Ngọc Thắng Nguyễn1,, Tiến Công Bùi2, Văn Thái Phạm2, Thị Thùy Trang Hoàng1
1 Nghean Oncology Hospital
2 Hanoi Medical University

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Abstract

Objective: Comment on some clinical and paraclinical characteristics, evaluate treatment results of patients with metastatic differentiated thyroid cancer treated with I-131 at Nghe an Oncology Hospital. Subject and method:  Cross sectional study, 230 patients with metastatic differentiated thyroid carcinoma who underwent total thyroidectomy were treated with I-131 at the Department of Nuclear Medicine, Nghe an Oncology Hospital from January 2018 to May 2021. Results:  The common age group is 21-55 years old and most of the patients are of working age, the average age is 47.5 ± 12.1. The rate of women with thyroid cancer is 5,5 times higher than the number of male patients, the pathological results show that papillary cancer accounts for the highest rate. In patients with lymph node metastasis who have undergone surgery, the rate of complete response is higher than in patients with nodal metastasis who have not had surgery. Therefore, in patients with cervical lymph node metastasis, lymph node dissection should be performed before radioactive iodine treatment. Cases of patients with lung and bone metastases often need to be treated with a large dose of I-131, but the treatment effect is not high.

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References

1. Mai Trọng Khoa (2009), "Đánh giá kết quả điều trị ung thư tuyến giáp thể biệt hóa di căn phổi bằng I-131", Y học lâm sàng, tr. 8-13.
2. Mai Trọng Khoa (2010), "Hiệu quả hủy của I-131 trong điều trị ung thư tuyến giáp thể biệt hóa.", Y học lâm sàng. Chuyên đề Y học hạt nhân và Ung thư, tr. 14-21.
3. Mai Trọng Khoa (2010), "Nghiên cứu ứng dụng Iốt phóng xạ I-131 điều trị bệnh ung thư biểu mô tuyến giáp thể biệt hóa".
4. Casara, D., Rubello, D., Saladini, G., Masorotto, G., Favero, A., Girelli, M.E., Busnardo, (1993), "Different features of pulmonary metastases in differentisted thyroid cancer: Natural history and multivariate statistical analysis of prognostic variables", J Nucl Med 34, tr. 1626-1632.
5. E.L, Mazzaferri (1997), Thyroid renanat I-131 ablation for papillary and follicular thyroid carcinoma, Thyroid 7, 265-271.
6. Ilgan, S. và các cộng sự. (2004), "Iodine-131 treatment and high-resolution CT: results in patients with lung metastases from differentiated thyroid carcinoma", Eur J Nucl Med Mol Imaging. 31(6), tr. 825-30.
7. Pineda J.D., Lee T (1995), "I-131 therapy for thyroid cancer patients with elevated thyroglobulin and negative scan", tr. 1488-1492.
8. Pittas, A. G. và các cộng sự. (2000), "Bone metastases from thyroid carcinoma: clinical characteristics and prognostic variables in one hundred forty-six patients", Thyroid. 10(3), tr. 261-8.
9. Ryan K. Orosco, Timon Hussain, Kevin T. Brumund et al, (2015), Analysis of Age and Disease Status as Predictors of Thyroid Cancer-Specific Mortality Using the Surveillance, Epidemiology, and End Results Database.