NGHIÊN CỨU THAY ĐỔI MỘT SỐ CYTOKINE TRONG BỆNH VẢY NẾN ĐỎ DA TOÀN THÂN

Abstract

Objectives: Study on concentrations of IL-2, IL-4, IL-6, IL-8, IL-10, IL-17, TNF-α, INF-γ in generalized erythrodermic psoriasis at Central Institute of Dermatology. Patients and methods: A prospective, cross-sectional descriptive study with comparative control was conducted. 30 patients with erythrodermic psoriasis without contraindications to Methotrexate and 30 healthy subjects similar in age and sex. Results: Before treatment: The patient group had concentrations of IL-2 (32.16 ± 79.53), IL-4 (5.72 ± 10.81), IL-6 (66.28 ± 221.61), IL- 8 (355.84 ± 508.11), IL-10 (5.95±10.42), IL-17 (11.55±9.23), TNF-α (6.56 ± 14.60), INF-γ(11.55 ± 9.23) 9,23), higher than the control group with p < 0.0001. There wasn’t relevance between the levels of cytokines and disease age, age and sex. After treatment: The concentrations of IL-6, IL-8 and TNF-α were reduced compared with before treatment with p<0.001, p<0.01, p<0.05 (in order). Conclusion: Concentrations of IL-2, IL-4, IL-6, IL-8, IL-10, IL-17, TNF-α, INF-γ in RTIs patients before treatment were higher than in healthy subjects and there was no relationship, without a relevance between cytokine levels and sex, disease age and age. Post-treatment cytokine levels were still higher than in the healthy group. Particularly, the concentration of IL-6, IL-8, TNF-α after treatment decreased compared to before treatment.