CLINICAL AND SUBCLINICAL CHARACTERISTIC OF DIQUAT POISONINGS AT THE POISON CONTROL CENTER OF BACH MAI HOSPITAL

Quốc Thái Bình Hoàng1,, Trần Hưng Hà1,2
1 Hanoi Medical University
2 Bach Mai Hospital

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Abstract

Diquat is a tremendous toxic herbicide and Diquat poisoning is an emerging public health problem in recent years. Objective: This study aimed to describe clinical, subclinical manifestation of Diquat poisoned patients at Poison Control Center of Bach Mai hospital. Subjects and methods: Observational study included all patients with diquat poisoning treat at the Poison Control Center from January 2021 to August 2022. Results: There were 68 patients poisoned with Diquat, 44 were male (70,6%) and 24 were female (29,4%), The most common age group was 30-39 years old (32,4%). The mortality rate was 64,7%. The clinical manifestations were involved in multi-organs: Acute kidney injury, brain, gastrointestinal, lung and refractory shock. The laboratory abnormality is metabolic acidosis with elevated anion gap, raise neutrophil, bilateral brain damages in computer tomography, severe lung infiltration in chest x-ray. Conclusion: The study revealed clinical manifestation Diquat poisoning is extremely severe with high mortality rate that need a effective management regiment.

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References

1. Jones GM, Vale JA. Mechanisms of toxicity, clinical features, and management of diquat poisoning: a review. J Toxicol Clin Toxicol. 2000;38(2):123-8.
2. Saeed SA, Wilks MF, Coupe M. Acute diquat poisoning with intracerebral bleeding. Postgrad Med J. 2001 May;77(907):329-32.
3. Schmidt DM, Neale J, Olson KR. Clinical course of a fatal ingestion of diquat. J Toxicol Clin Toxicol. 1999;37(7):881-4.
4. Basilicata P, Pieri M, Simonelli A, Capasso E, Casella C, Noto T, Policino F, Di Lorenzo P. Diquat Poisoning: Care Management and Medico-Legal Implications. Toxics. 2022 Mar 30
5. Chen YX. [Imaging features of 10 patients with toxic encephalopathy caused by diquat]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2022 May 20;40(5):362-365. Chinese.
6. Guck D, Hernandez R, Moore S, Van de Louw A, Haouzi P. Rapid Glomerulotubular Nephritis as an Initial Presentation of a Lethal Diquat Ingestion. Case Rep Nephrol. 2021 Sep 11.
7. Feng D, Fu L, Du X, Yao L. Acute diquat poisoning causes rhabdomyolysis. Am J Med Sci. 2022 May 2.
8. Cai XL, Teng F, Yu X, Liu LL, Li GQ. [Four cases of acute diquat poisoning with prominent epileptoid seizure and literature review]. Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2021 May 20;39(5):359-362. Chinese.
9. Zhou JN, Lu YQ. Lethal diquat poisoning manifests as acute central nervous system injury and circulatory failure: A retrospective cohort study of 50 cases. EClinicalMedicine. 2022 Aug 11.
10. Yu G, Jian T, Cui S, Shi L, Kan B, Jian X. Acute diquat poisoning resulting in toxic encephalopathy: a report of three cases. Clin Toxicol (Phila). 2022 May;60(5):647-650.