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Date Published: 21/02/2023
Abstract Views: 243
Views PDF: 110
DOI: https://doi.org/10.51298/vmj.v521i2.4065
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Vol. 521 No. 2 (2022)
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Nguyễn, T. H., & Dương, H. H. (2023). MICROSATELLITE INSTABILITY STATUS IN COLORECTAL CANCER AT HA NOI ONCOLOGY HOSPITAL. Vietnam Medical Journal, 521(2). https://doi.org/10.51298/vmj.v521i2.4065 (Original work published February 15, 2023)

MICROSATELLITE INSTABILITY STATUS IN COLORECTAL CANCER AT HA NOI ONCOLOGY HOSPITAL

Thị Hải Nguyễn1,2,, Hoàng Hảo Dương1
1 Hanoi Oncology Hospital
2 Hanoi medical university

Main Article Content

Abstract

Introduction: Microsatellite instability (MSI) is one of three major mechanisms in colorectal (CRC) carcinogenesis. MSI has been identified as a reliable prognostic indicator in CRC, with an additional role in predicting the lack of benefit of 5-FU-based adjuvant chemotherapy. It also helps screen for lynch syndrome. Objective: Evaluate MSI status, clinical patterns in   CRCs   and   correlate   with histopathology at Ha Noi Oncology Hospital. Methods: 96 patients with colorectal cancer were studied by Immunohistochemistry (IHC) method with MLH1, PMS2, MSH2, MSH6 markers. Result: MSI rate is 29.2%; Rate of clinical patterns base on IHC: sporadic CRCs: 70.8%, unclear: 17.7%, LS: 11,5%. Tumor infiltrating   lymphocytes and Crohn's-like lymphoid reaction status have significant correlation with MSI status and LS (p<0,05). Other factors such as histologic type, histologic grade, lymph node status, and infiltration were not found to have statistically significant associations with microsatellite instability and LS. (p>0,05). Conclusion: MSI rate is 29.2%; Rate of clinical patterns base on IHC: sporadic CRC: 70.8%, unclear: 17.7%, Lynch (LS): 11,5%; CRCs with MSI and LS have characteristic histopathological features: Tumor infiltrating lymphocytes and Crohn's-like lymphoid reaction.

Article Details

Keywords

Microsatellite instability (MSI), histopathology, Immunohistochemistry, Lynch syndrome.

References

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