MỘT SỐ YẾU TỐ TIÊN LƯỢNG CỦA PHỔ BỆNH VIÊM TỦY THỊ THẦN KINH

Abstract

Objective: Analyze some prognostic factors of neuromyelitis optica spectrum disorders (NMOSD). Subjects: We selected 38 patients were diagnosed with neuromyelitis optica with positive Anti-Aquaporin 4 antibody between January 2020 and June 2022 at the Neurology Center of Bach Mai Hospital. Methods: Cross-sectional descriptive study. Results: Study on 38 patients diagnosed with NMOSD with positive Anti-Aquaporin 4 antibody, mainly female patients with 31 (approximately 81.6%) with a male/female ratio of 1:4.28 and age group. Most patient are middle-aged (30-49 years old, accounting for 52.6%) and the average age is 41.9 ± 13.8 years old. The most common symptoms were pyramidal symptoms (motor paralysis) and sensory disturbances accounting for the majority of patients 89.5% and 86.5%, followed by optic nerve symptoms with 21.1% and brainstem symptoms with 18.4%. It has not been found that gender is a factor that can help predict disability with EDSS score between the two sexes not statistically significant at both the time of admission and discharge with p=0.141 and 0.433. The symptoms of motor paralysis could predict a higher degree of disability in patients with a statistically significant increase in EDSS score between the quadriplegic group and the paraplegic group as well as between the paraplegic and non-paraplegic group. both survey times with p=0.007 and 0.015, p=0.013 and 0.011. Patient age has a mean positive linear correlation with EDSS score at both the time of admission and discharge with correlation coefficients r=0.401 and 0.338, respectively, with p=0.013 and 0.038, 95% confidence. The group of patients Independent of support (EDSS < 6) had a statistically significant lower age than and Patients Dependent of Support (EDSS ≥ 6) with p=0.015. Conclusion: In summary, through the study Analysis of some prognostic factors of the spectrum of neuromyelitis optica, we found that the spectrum of neuromyelitis optica is a common autoimmune disease in women, the average age of age, with prominent symptoms of motor paralysis and symptoms of the optic nerve (blurred vision, pain,...). Gender is not a prognostic factor, the more severe the initial motor paralysis, the greater the extent of disability according to Kurtzke of the patient, similar to the age of the patient.