TÌNH TRẠNG TỔN THƯƠNG GAN DO DỊ ỨNG THUỐC TẠI BỆNH VIỆN ĐÀ NẴNG

Abstract

Objective: To evaluate the liver injury of drug-allergic patients at Da Nang Hospital. Subjects and Methods: A cross-sectional and retrospective descriptive study on 444 patients with drug allergies from January 2018 to May 2022 at Da Nang Hospital. Results: The average age of the study subjects was 45,68 ± 16,85 years old, the oldest was 86 years old, the youngest was 15 years old. There were 19,9% ​​and 22,3% of drug-allergic patients with increased SGOT and SGPT above the upper limit of normal. The average concentration of SGOT and SGPT of the study group of patients was 33,76 ± 45,15 U/L and 38,70 ± 55,65 U/L. DRESS syndrome had the most severe liver injury with a mean SGOT of 182,06 ± 88,53 (U/L) and a mean SGPT of 364,73 ± 171,01 U/L. There are many drugs that cause liver injury, in which the two drugs that cause liver enzyme elevation the most are anti-tuberculosis drugs (SGOT: 104,45 ± 90,43 U/L; SGPT: 170,35 ± 256,0 U/L) and allopurinol (SGOT: 134,35 ± 188,71 U/L; SGPT: 147,24 ± 112,98 U/L). Severe skin lesions (Lyell syndrome, SJS, DRESS, generalized erythema) all had low mean albumin < 35g/L. Conclusion: Liver injury is a common lesion in drug-allergic patients in which DRESS syndrome is the clinical form causing the most severe liver injury. Anti-tuberculosis drugs, allopurinol, are the drugs that cause the most severe liver injury. Serum albumin concentration in severe drug allergies is usually < 35 g/L.