ĐÁNH GIÁ SỰ THAY ĐỔI CỦA TÂN MẠCH TRÊN OCTA SAU TIÊM NỘI NHÃN BEVACIZUMAB ĐIỀU TRỊ THOÁI HÓA HOÀNG ĐIỂM TUỔI GIÀ

Abstract

Objective: Evaluate of the change of choroidal neovascularization by optical coherence tomography angiography after intravitreal injection Bevacizumab in wet age-related macular degeneration. Method : Prospective descriptive study on 28 eyes of 27 patients with exudative age-related macular degeneration who were indicated for intraocular injection of Bevacizumab after 1 month, 2 months and 3 months from 10/2021 to 8/2022 at the Department of Ophthalmology - National Geriatric Hospital. Results: 28 eyes of 27 patients were included in the study, with 3 types of neovascularization: type 1, type 2 and type 3, in which CNV type 1 accounts for the highest rate (75%), followed by type 2 (21.4%) and type 3 (3.6%). Qualitatively, the neovascular shape has changed markedly after 3 months of injection of Bevacizumab, from neovascularizationwith obvious shapes such as medusa, seafan to the decrease and disappearance of the surrounding capillary system. and the branching circuit is small, but the central root circuit is little changed. Quantitatively, the average neovascular area measured was 1.54±0.89 mm², after the loading phase the area decreased by 39.6% to 0.93 ±0.75m². Vascular density, perfusion density the central area is lower than the inner area and in the total, after 3 months in general these parameters decrease but this decrease is not statistically significant. Conclusion: OCTA provides detailed images of the qualitative and quantitative characteristics of CNV, with high reliability and safety allowing us to repeat the survey many times during the treatment follow-up. The effect of Bevacizumab after the loading phase, there were significant changes in both shape and size on OCTA