TỐI ƯU HÓA QUY TRÌNH ĐIỀU CHẾ CAO PHUN SẤY BƯỞI NON

Abstract

Objectives: The study aimed to find the optimal conditions for the production of young pomelo spray-drying extract with multi-objective optimization using the desirability function approach. Subjects and methods: 20 laboratory experiments were conducted to build the objective function that describes the drying air temperature, the air flow, the influence and rate of exipients to the spray drying process. Results: By means of expected function it was able to solve multiobjective optimization for determining the optimal mode for young pomelo spray-drying extract translated as follows: drying air temperature 160 ^oC, air flow 200 m³/h, type carrier maltodextrin – aerosil (2:1) and the ratio of carrier 70 % to the solids in the extract. At this condition, the performance reached 45.03 %, the flavonoid content was 19.58 %, the density was 0.34 g/ml, and the compression fraction was 23.05%. Conclusion: Experimental model has been designed and suscessfully optimized for the spray drying process of young pomelos using Design-Expert software version 12.0.3.0. This is an important basis for the development of modern dosage forms containing young pomelo extract such as tablets or capsules.