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Date Published: 17/02/2023
Abstract Views: 130
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DOI: https://doi.org/10.51298/vmj.v520i2.4159
Issue
Vol. 520 No. 2 (2022)
Section
Các bài báo
How to Cite
Nguyễn, T. H., Nguyễn, T. N., Trần, T. M. H., & Nguyễn, T. T. H. (2023). ASSOCIATION BETWEEN FAT MASS AND OBESITY-ASSOCIATED (FTO) GENE POLYMORPHISM RS1121980 AND OSTEOPOROSIS IN MEN. Vietnam Medical Journal, 520(2). https://doi.org/10.51298/vmj.v520i2.4159

ASSOCIATION BETWEEN FAT MASS AND OBESITY-ASSOCIATED (FTO) GENE POLYMORPHISM RS1121980 AND OSTEOPOROSIS IN MEN

Thị Hoa Nguyễn1,, Thị Nàn Nguyễn1, Thị Minh Hoa Trần2, Thị Thanh Hương Nguyễn3,4
1 Huu Nghi hospital
2 Bach Mai hospital
3 Hanoi medical university
4 Dinh Tien Hoang Institute of medicine

Main Article Content

Abstract

Recent studies have shown that the FTORs1121980 gene polymorphism reduces bone density in postmenopausal women and increases the risk of their femoral neck fractures, but no studies in men have been performed. Therefore, our study aimed to determine the polymorphism of the FTOrs1121980 gene and the association of this gene polymorphism with male osteoporosis. Subjects and methods: A case-control study was conducted on 400 men aged 50 years and older (200 diseases and 200 controls) and the BMD (bone mineral density) value was determined by measuring dual-energy X-ray absorptiometry, at the site of L1-L4 vertebrae, femoral neck and superior femoral head. The group of patients was diagnosed with osteoporosis according to WHO criteria, the control group was the group with normal bone density. Genotyping FTOrs1121980 by RFLP-PCR (Rectriction Fragment Length Polymorphism-Polymerase Chain Reaction) to check the accuracy by sequencing some samples. Analyze the association between this gene polymorphism and male osteoporosis by OR index. Results: The frequency of genotype GG/GA/AA of the study group was: 62%/38%/0%, respectively, without the occurrence of homozygous AA genotype in 400 study subjects. The proportions of G and A alleles are 81.17 and 12.43%, respectively, of the genotype distribution, and the allele does not obey Hardy-Weinberg law. Genotype AG appeared at a high rate in the disease group compared with the control group, the difference was statistically significant with p < 0.05. Genotype GA increases the risk of lumbar spine osteoporosis by 1.99 times compared with GG genotype (95% CI :1.31 - 3.06), the difference is statistically significant with p<0.005; Similarly, the A allele increases the risk of lumbar spine osteoporosis 1.63 times compared with the G allele (95% CI: 1.17–2.43) (p=0.005). Conclusion: The results of our study indicate that the FTO rs1121980 gene polymorphism is a risk factor for lumbar spine osteoporosis in men.

Article Details

Keywords

fat mass and obesity-associated; Polymorphism (Genetic); Osteoporosis, Bone Mineral Density; Men

References

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