ĐÁNH GIÁ TỔN THƯƠNG KHU TRÚ LỚP SỢI THẦN KINH QUANH ĐĨA THỊ TRÊN BỆNH NHÂN GLÔCÔM GÓC MỞ NGUYÊN PHÁT

Abstract

Purposes: To evaluate focal damage of the peripapillary retinal nerve fiber layer (RNFL) in patients with primary open-angle glaucoma in latent (preperimetric), early and moderate stages according to GSS, Mills 2006 classification and correlation between functional and structural damage. Methods: Cross-sectional study. All participants have throughout eye exam, a 24-2 visual field test on Humphrey machine is conducted. RNFL is accessed by Cirrus HD-OCT 5000, protocol Optic Disk Cube 200x200, ONH and RNFL Analysis. Results: We conducted a study on 146 eyes of 99 primary open-angle glaucoma patients. There is a significant change in the thickness of the nerve fiber layer according to the market stages at the positions of average (p=0.009), upper (p=0.034), lower (p=0.002), 5 hours (p=0.025), 6 hours (p=0.012) with a confidence level of over 95% (p<0.05). There is a significant correlation between the mean nerve fiber layer thickness, the upper and lower nerve fiber layer thickness and the positions 1 o'clock, 2 o'clock, 5 to 7 o'clock, 11 and 12 o'clock with the indices. market with p < 0.05. The strongest correlation is shown in the lower quadrant position with the MD, PSD and VFI indexes of 0.341, 0.334 and 0.31 respectively. Conclusion: The focal defect of the RNFL is significantly modified in patients with early primary open-angle glaucoma, however, the rate of focal defect in 1 clock hour  are small and need further study. The average RNFL thickness and several locations were weakly correlated with early visual field damage.