OUTCOMES OF AUTOLOGOUS BONE MARROW MONONUCLEAR CELL ADMINISTRATION IN COMBINATION WITH NEUROLOGICAL REHABITATION FOR TRAUMATIC BRAIN INJURY PATIENT
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Abstract
Objective: The aim of this study is to assess the potential effectiveness of autologous bone marrow mononuclear cell administration in combination with neurological rehabitation in patients after traumatic brain injury. Methods: The study was a Phase I clinical trial comparing the effectiveness of the treatment in 25 patients with closed traumatic brain injury occurred within 6 to 36 months. The patient received an autologous mononuclear stem cell transplant from bone marrow, combined with rehabilitation for 6 months with the follow-up visits at the 3rd and 6th month. Results: At the end of the study, significant improvements were observed in independent functional score (FIM); reducing disability grade in the Glasgow Outcome Scale - extended (GOSE); as well as quality of life according to the SF-36 scale.
Article Details
Keywords
Stem cells, traumatic brain injury, neurological rehabilitation
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