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Date Published: 17/02/2023
Abstract Views: 191
Views PDF: 149
DOI: https://doi.org/10.51298/vmj.v520i2.4167
Issue
Vol. 520 No. 2 (2022)
Section
Các bài báo
How to Cite
Hà, T. H. G., Phạm, V. M. ., Nguyễn, T. N. T., & Nguyễn, T. L. (2023). OUTCOMES OF AUTOLOGOUS BONE MARROW MONONUCLEAR CELL ADMINISTRATION IN COMBINATION WITH NEUROLOGICAL REHABITATION FOR TRAUMATIC BRAIN INJURY PATIENT. Vietnam Medical Journal, 520(2). https://doi.org/10.51298/vmj.v520i2.4167

OUTCOMES OF AUTOLOGOUS BONE MARROW MONONUCLEAR CELL ADMINISTRATION IN COMBINATION WITH NEUROLOGICAL REHABITATION FOR TRAUMATIC BRAIN INJURY PATIENT

Thị Hương Giang Hà1,, Văn Minh Phạm1, Thị Ngọc Thủy Nguyễn1, Thanh Liêm Nguyễn2
1 Hanoi medical university
2 VINMEC INTERNATIONAL GENERAL HOSPITAL

Main Article Content

Abstract

Objective: The aim of this study is to assess the potential effectiveness of autologous bone marrow mononuclear cell administration in combination with neurological rehabitation in patients after traumatic brain injury. Methods: The study was a Phase I clinical trial comparing the effectiveness of the treatment in  25 patients with closed traumatic brain injury occurred within 6 to 36 months. The patient received an autologous mononuclear stem cell transplant from bone marrow, combined with rehabilitation for 6 months with the follow-up visits at the 3rd and 6th month. Results: At the end of the study, significant improvements were observed in independent functional score (FIM); reducing disability grade in the Glasgow Outcome Scale - extended (GOSE); as well as quality of life according to the SF-36 scale.

Article Details

Keywords

Stem cells, traumatic brain injury, neurological rehabilitation

References

1. Jennett B. Epidemiology of head injury. Arch Dis Child. 1998;78(5):403-406.
2. Hwang PY, Lewis PM, Balasubramani YV, Madan A, Rosenfeld JV. The epidemiology of BCVI at a single state trauma centre. Injury. 2010;41(9):929-934.
3. Pham CV, Luong AM, Bachani AM, Nguyen TV, Tran NT, La QN. Injury Mortality in Vietnam: Patterns and Trends, 2005-2013. J Public Health Manag Pract JPHMP. 2018;24 Suppl 2:S44-S51.
4. Nguyễn Duy Thăng, Nguyễn Viết Quang, Trần Ngọc Vũ, Hà Thị Phương Lan, Bùi Thị Diễm Thu. Điều trị chấn thương sọ não cấp tính bằng ghép tế bào gốc tự thân tại bệnh viện Trung ương Huế. Tạp Chí Học Lâm Sàng. 2020;59:20-25.
5. Sharma AK, Sane HM, Kulkarni PP, Gokulchandran N, Biju H, Badhe PB. Autologous bone marrow mononuclear cell transplantation in patients with chronic traumatic brain injury- a clinical study. Cell Regen Lond Engl. 2020;9(1):3.
6. Vũ Minh Hải. Tỉ lệ, đặc điểm và thái độ xử trí chấn thương sọ não máu tụ ngoài màng cứng tịa bệnh viện đa khoa tỉnh Thái Bình. Tạp Chí Học Việt Nam. 2021;503(1):257-260.
7. Sharma A, Sane H, Gokulchandran N, et al. A clinical study of autologous bone marrow mononuclear cells for cerebral palsy patients: a new frontier. Stem Cells Int. 2015;2015:905874.
8. Bedi SS, Walker PA, Shah SK, et al. Autologous bone marrow mononuclear cells therapy attenuates activated microglial/macrophage response and improves spatial learning after traumatic brain injury. J Trauma Acute Care Surg. 2013;75(3):410-416.