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Date Published: 17/02/2023
Abstract Views: 281
Views PDF: 190
DOI: https://doi.org/10.51298/vmj.v520i2.4196
Issue
Vol. 520 No. 2 (2022)
Section
Các bài báo
How to Cite
Bùi, C. B., Châu, H. V. H., Vũ, B. T. ., & Trương, H. T. T. (2023). THE PREVALENCE OF ANTI NMDA, AMPAR1/R2, GABABR, LGI1, CASPR2 RECEPTOR ANTIBODIES IN PEDIATRIC AUTOIMMUNE ENCEPHALITIS. Vietnam Medical Journal, 520(2). https://doi.org/10.51298/vmj.v520i2.4196

THE PREVALENCE OF ANTI NMDA, AMPAR1/R2, GABABR, LGI1, CASPR2 RECEPTOR ANTIBODIES IN PEDIATRIC AUTOIMMUNE ENCEPHALITIS

Chí Bảo Bùi1,, Huỳnh Vũ Hương Châu1, Bảo Trâm Vũ1, Huỳnh Thanh Thúy Trương1
1 City Children’s Hospital

Main Article Content

Abstract

Introduction: Autoimmune Encephalitis (AE) includes a group of inflammatory disorders caused by local or systemic effects of antibodies on the limbic brain of the central nervous system. This disease is rare and occurs in both adults and children. Recent studies showed a significant increase in the proportion of AE patients. Objective: To determine the rate of anti-NMDAR, AMPAR1/R2, GABABR, LGI1, CASPR2 antibodies, and some clinical and paraclinical features in pediatric autoimmune encephalitis. Materials and method: A descriptive study was conducted on 10 AE patients at City Children's Hospital from 01/2022 to 07/2022. Cerebrospinal fluid and plasma samples were collected to investigate autoantibodies by indirect immunofluorescence assay (IFA). Result: The positive rate of anti-NMDAR antibodies was 80%, AMPAR1/R2 was 10%, GABABR was 10%, and there have been no positive cases with anti-LGI1, CASPR2 receptor antibodies and simultaneously positive for many different types of antibodies. Conclusion: The positive rate of anti-NMDA receptor antibodies still accounts for the highest rate. Besides, it is crucial to determine other anti-receptor antibodies such as AMPAR1/R2, GABABR, LGI1, CASPR2, etc. For further early diagnosis and appropriate therapy, to bring the best treatment results for the patients. 

Article Details

Keywords

Autoimmune encephalitis, Anti NMDAR encephalitis, Anti AMPAR1/R2 encephalitis, Anti GABABR encephalitis, Anti LGI1 encephalitis, Anti CASPR2 encephalitis.

References

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