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Date Published:
17/02/2023
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Views PDF: 368
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Nguyễn, T. D. H., Trương, M. N., Mai, H. N., Trịnh , T. D. T., & Nguyễn, H. L. T. (2023). EVALUATE ACUTE TOXICITY AND HEPATOPROTECTIVE EFFECT OF YOUNG POMELO EXTRACT AGAINST CCL4 INDUCED LIVER INJURY IN MICE. Vietnam Medical Journal, 520(2). https://doi.org/10.51298/vmj.v520i2.4199
EVALUATE ACUTE TOXICITY AND HEPATOPROTECTIVE EFFECT OF YOUNG POMELO EXTRACT AGAINST CCL4 INDUCED LIVER INJURY IN MICE
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Abstract
The maximum dose of 13.084 g young pomelo extract did not cause abnormality and death in mice. The protective effects of young pomelo extracts on the model of CCl4 was evident in AST level, demonstrated by a decrease in MDA, a slight increase in GSH, and a decrease in the hepatic necrosis. In conclusion, young pomelo extract with the dose 1,3 g/kg had mild protective activity in a model of hepatitis induced by high doses of CCl4
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độc tính cấp; bảo vệ gan; cao bưởi non
References
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2. Brunt E. M. (2000), "Grading and staging the histopathological lesions of chronic hepatitis: the Knodell histology activity index and beyond", Hepatology. 31 (1), pp. 241-246.
3. Draper H. et al. (1993), "A comparative evaluation of thiobarbituric acid methods for the determination of malondialdehyde in biological materials", Free Radical Biology Medicine. 15 (4), pp. 353-363.
4. Rahman I. et al. (2006), "Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method", Nature protocols. 1 (6), pp. 3159-3165.
5. Scholten D. et al. (2015), "The carbon tetrachloride model in mice", Laboratory animals. 49 (1_suppl), pp. 4-11.
6. Zhu R. et al. (2013), "Oroxylin A accelerates liver regeneration in CCI4-induced acute liver injury mice", PloS one. 8 (8), pp. e71612