EVALUATE ACUTE TOXICITY AND HEPATOPROTECTIVE EFFECT OF YOUNG POMELO EXTRACT AGAINST CCL4 INDUCED LIVER INJURY IN MICE
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Abstract
The maximum dose of 13.084 g young pomelo extract did not cause abnormality and death in mice. The protective effects of young pomelo extracts on the model of CCl4 was evident in AST level, demonstrated by a decrease in MDA, a slight increase in GSH, and a decrease in the hepatic necrosis. In conclusion, young pomelo extract with the dose 1,3 g/kg had mild protective activity in a model of hepatitis induced by high doses of CCl4
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Keywords
độc tính cấp; bảo vệ gan; cao bưởi non
References
Bộ Y Tế (2015), "Hướng dẫn thử nghiệm tiền lâm sàng và lâm sàng thuốc đông y, thuốc từ dược liệu", Quyết định số 141.
2. Brunt E. M. (2000), "Grading and staging the histopathological lesions of chronic hepatitis: the Knodell histology activity index and beyond", Hepatology. 31 (1), pp. 241-246.
3. Draper H. et al. (1993), "A comparative evaluation of thiobarbituric acid methods for the determination of malondialdehyde in biological materials", Free Radical Biology Medicine. 15 (4), pp. 353-363.
4. Rahman I. et al. (2006), "Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method", Nature protocols. 1 (6), pp. 3159-3165.
5. Scholten D. et al. (2015), "The carbon tetrachloride model in mice", Laboratory animals. 49 (1_suppl), pp. 4-11.
6. Zhu R. et al. (2013), "Oroxylin A accelerates liver regeneration in CCI4-induced acute liver injury mice", PloS one. 8 (8), pp. e71612
2. Brunt E. M. (2000), "Grading and staging the histopathological lesions of chronic hepatitis: the Knodell histology activity index and beyond", Hepatology. 31 (1), pp. 241-246.
3. Draper H. et al. (1993), "A comparative evaluation of thiobarbituric acid methods for the determination of malondialdehyde in biological materials", Free Radical Biology Medicine. 15 (4), pp. 353-363.
4. Rahman I. et al. (2006), "Assay for quantitative determination of glutathione and glutathione disulfide levels using enzymatic recycling method", Nature protocols. 1 (6), pp. 3159-3165.
5. Scholten D. et al. (2015), "The carbon tetrachloride model in mice", Laboratory animals. 49 (1_suppl), pp. 4-11.
6. Zhu R. et al. (2013), "Oroxylin A accelerates liver regeneration in CCI4-induced acute liver injury mice", PloS one. 8 (8), pp. e71612