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Date Published: 17/02/2023
Abstract Views: 213
Views PDF: 391
DOI: https://doi.org/10.51298/vmj.v520i2.4203
Issue
Vol. 520 No. 2 (2022)
Section
Các bài báo
How to Cite
Trần, T. C. M. (2023). APPLICATION OF BIOLOGICAL VARIATION IN MEDICAL LABORATORY PRACTICE. Vietnam Medical Journal, 520(2). https://doi.org/10.51298/vmj.v520i2.4203

APPLICATION OF BIOLOGICAL VARIATION IN MEDICAL LABORATORY PRACTICE

Thị Chi Mai Trần1,2,
1 Hanoi medical university
2 Vietnam National Children's Hospital.

Main Article Content

Abstract

Categories of biological variation include intraindividual variation and interindividual variation. Biological variability is not only fundamental in the interpretation of test results, but also influences clinical decisions. Biological variability is used to set laboratory analytical goals. The concept of reference change value (RCV) based on analytical and individual variations is developed to determine whether a difference between consecutive results of one analyte in a patient might have clinical significance. The concept introduces a scientific approach to an area where clinicians have largely relied on their intuition and experience. Index of individuality (II) allows a comparison of intraindividual biological variation to interindividual variation, so it helps to assess the utility of conventional reference values. Personalized reference intervals can be calculated using estimates of biological and analytical variation and previous test results obtained in s steady-state situation.

Article Details

Keywords

intraindividual biological variation, interindividual biological variation, reference change value, Index of Individuality, laboratory analytical goals

References

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