XÁC ĐỊNH GIÁ TRỊ TRUNG VỊ CỦA MỘT SỐ CHỈ SỐ HÓA SINH TRONG SÀNG LỌC TRƯỚC SINH (β-HCG TỰ DO, PAPP–A, NT)

Abstract

Congenital anomaly are one of the most common abnormalities in fetuses and newborns. There are many causes of congenital anomaly, of which genetic disorders at the chromosomal level have the most severe consequences. To diagnose chromosomal abnormalities, before conducting invasive pregnancy tests, laboratories are assigned double test in pregnancy I or triple test in pregnancy II. For the dual trial, the quantitative results of β-HCG and blood PAPP-A, combined with ultrasound results such as nuchal translucency (NT), rumpback length (CRL) will be converted to the multiple center MoM in the week of the clothes, calculating the risk value of disease for each fetus according to the possible rate of determination.  This value is subject to change in the pre-feature to the percestation 7. Several recent studies have shown the difference between average value in the experimental population and the software, from available parts, thus helping complete the accuracy and reliability of the filtered value.  We therefore do this study to determine the central MoM values ​​of some biochemical indicators in prenatal screening (β-HCG, PAPP-A and NT). We conducted a survey on 1265 pregnant women who were double test with gestational weeks from 11 weeks to 13 weeks and 6 days respectively. According to the results, there is a difference in β-HCG, PAPP-A, NT in our study compared to those used in other brands, specific values ​​are in the content of the article. The median MOM value after being established for effective prenatal screening in Vietnamese pregnant women.