PROGRESSION FREE SURVIVAL AND SOME FACTORS AFFECTING IN ADVANCED LUNG CANCER TREATED PEMBROLIZUMAB

Thanh Đức Lê1,, Thị Thu Hà Nguyễn2
1 Nation cancer hospital
2 Hanoi medical university

Main Article Content

Abstract

Aims: Evaluation of progression-free survival time and some factors related to the time of progression-free survival in patients with advanced non-small cell lung cancer treated with Pembrolizumab monotherapy. Research subject: 32 patients diagnosed with recurrent or metastatic NSCLC were treated with pembrolizumab monotherapy at K hospital from October 2017 to July 2020. Patients and Methods: Retrospective combined prospective study. Results: The mean PFS was 8,0±1,95 months. Higher PFS in male patients. Conclusion: pembrolizumab improves progression free survival and is related to gender.

Article Details

References

1. Socinski MA, Evans T, Gettinger S, et al. Treatment of stage IV non-small cell lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. 2013;143(5 Suppl):e341S-e368S.
2. Forde PM, Ettinger DS. Targeted therapy for non-small-cell lung cancer: past, present and future. Expert Rev Anticancer Ther. 2013;13(6):745-758.
3. Reck M, Rodríguez–Abreu D, Robinson AG, et al. Updated Analysis of KEYNOTE-024: Pembrolizumab Versus Platinum-Based Chemotherapy for Advanced Non–Small-Cell Lung Cancer With PD-L1 Tumor Proportion Score of 50% or Greater. JCO. 2019;37(7):537-546.
4. Borghaei H, Langer CJ, Gadgeel S, et al. 24-Month Overall Survival from KEYNOTE-021 Cohort G: Pemetrexed and Carboplatin with or without Pembrolizumab as First-Line Therapy for Advanced Nonsquamous Non-Small Cell Lung Cancer. J Thorac Oncol. 2019;14(1):124-129.
5. Herbst RS, Baas P, Kim D-W, et al. Pembrolizumab versus docetaxel for previously treated, PD-L1-positive, advanced non-small-cell lung cancer (KEYNOTE-010): a randomised controlled trial. The Lancet. 2016;387(10027):1540-1550.
6. Wang C, Qiao W, Jiang Y, et al. Effect of sex on the efficacy of patients receiving immune checkpoint inhibitors in advanced non‐small cell lung cancer. Cancer Med. 2019;8(8):4023-4031.
7. Berland L, Heeke S, Humbert O, et al. Current views on tumor mutational burden in patients with non-small cell lung cancer treated by immune checkpoint inhibitors. J Thorac Dis. 2019;11(Suppl 1):S71-S80.
8. Paz-Ares L, Luft A, Vicente D, et al. Pembrolizumab plus Chemotherapy for Squamous Non–Small-Cell Lung Cancer. New England Journal of Medicine. 2018;379(21):2040-2051.