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Date Published: 19/02/2023
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DOI: https://doi.org/10.51298/vmj.v522i1.4261
Issue
Vol. 522 No. 1 (2023)
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Các bài báo
How to Cite
Đỗ, H. K., & Nguyễn, V. T. (2023). STUDY OF CLINICAL AND SUBCLINICAL FEATURES OF PATIENTS DIAGNOSED OF ADVANCED/METASTATIC NON-SMALL CELL LUNG CANCER ACQUIRED RESISTED TO EGFR TKIS FIRST- AND SECOND-GENERATIONS. Vietnam Medical Journal, 522(1). https://doi.org/10.51298/vmj.v522i1.4261

STUDY OF CLINICAL AND SUBCLINICAL FEATURES OF PATIENTS DIAGNOSED OF ADVANCED/METASTATIC NON-SMALL CELL LUNG CANCER ACQUIRED RESISTED TO EGFR TKIS FIRST- AND SECOND-GENERATIONS

Hùng Kiên Đỗ1,, Văn Tài Nguyễn1
1 National cancer hospital

Main Article Content

Abstract

Objective: Describing the clinical and subclinical features of patients diagnosed of advanced/ metastatic non-small cell lung cancer acquired resistance to EGFR TKIs first- and second-generations at National Cancer Hospital from 01/2017 to 05/2022. Patients and method: Retrospective and prospective analysis of 85 patients with advanced/ metastatic non-small cell lung carcinoma acquired resistance to EGFR TKIs first- and second-generations were diagnosed and treated at National Cancer Hospital from 01/2017 to 05/2022. Results: The average age was 58.2±8.2, rate of male patients was 50.9%. Rate of smoking accounted for 40% and rate of medical history of chronic obstructive pulmonary disease accounted for 23.6%. The common symptoms of advanced lung cancer patients were dry cough, chest pain and dyspnea, accounting for 80%; 74.5% and 60%, respectively. For performance status, ECOG 1 accounted for 44.5%. The common metastatic locations in our patients were bone, lung and pleural/pericardial metastases, accounting for 67.3%; 63.6% and 58.2%, respectively. There were 64.7% of cases had progressed in primary lung tumor and mediastinal nodes. Most of patients underwent lung tumor biopsies (48.2%), cellblock of pleural fluid (17.6%) at the time of progressive disease. Conclusion: Advanced/metastatic EGFR-positive non-small cell lung cancer often occured in middle-older aged patients without history of smoking. The common clinical symptoms were dry cough, chest pain and dyspnea with presence of bone and lung metastases.

Article Details

Keywords

Non-small cell lung cancer, advanced/ metastatic stage, resistance to EGFR TKIs

References

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