HIỆU QUẢ ĐIỀU TRỊ LOÉT TÁ TRÀNG CÓ NHIỄM HELICOBACTER PYLORI

Abstract

Objective: To evaluate the effectiveness of treatment of duodenal ulcers with H. pylori infection with a 4-drug regimen of rabeprazole - bismuth - tetracycline - tinidazole. Subjects and methods: The study was carried out at Can Tho University of Medicine and Pharmacy Hospital from January 2015 to December 2016. We performed gastrointestinal endoscopy on diagnosis, evaluation of duodenal ulcer, gastric mucosa biopsy for rapid urease test and histopathological diagnosis of H. pylori. Treatment of eradication of H. pylori bacteria with a 4-drug regimen rabeprazole - bismuth - tetracycline - tinidazole. Finally, the effectiveness of duodenal ulcer treatment was evaluated by second upper gastrointestinal endoscopy, gastric mucosal biopsy, urease test and histopathology to diagnose H. pylori. Results: 102 patients participated in the study, 92 patients returned for follow-up visits. Duodenal ulcers are mainly located at D1 duodenum, accounting for 98%. D1 duodenal ulcer on the anterior surface accounts for 60.8%, size from 5 to 9mm accounts for 65%. Most patients had 1 duodenal ulcer, accounting for 84.3%. The rate of patients with duodenal ulcer healing was 96.7% (95% CI: 92.4-100). There was no difference in the effectiveness of duodenal ulcer treatment by age group, gender, alcohol consumption, smoking, H. pylori treatment results and clinical symptoms. Conclusion: Treatment of duodenal ulcer combined with H. pylori eradication treatment with a regimen of 4 drugs rabeprazole - bismuth - tetracycline - tinidazole achieved high efficiency in ulcer healing.