IGE ĐẶC HIỆU VỚI 52 DỊ NGUYÊN VÀ MỐI LIÊN QUAN VỚI MỘT SỐ ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG TRÊN BỆNH NHÂN MÀY ĐAY MẠN TÍNH

Abstract

Objectives: Describe the results and investigate the relationship of Immunoglobin E (IgE) specific to 52 allergen-specific IgE - sIgE and the relationship with some subclinical characteristics of patients with chronic urticaria. Research object and method: Subjects: 265 patients diagnosed with chronic urticaria from 08/2021 to 08/2022 at the National Hospital of Dermatology were assigned to test for 52 allergens that met the inclusion and exclusion criteria. Research method: cross-sectional description. Result: in 265 patients studied: The group of environmental allergens has the highest and strongest rate of sIgE positivity in which: farina dust is very strongly positive at 1.5%; Peter dust is very strongly positive at 0.4%; cat hair strongly positive at 0.4% Blomia dust is strongly positive at 1.5%; Bermuda grass strongly positive 0.4%. Next is the group of insect allergens: wasp venom is strongly positive at 2.3%; fire ants are strongly positive at 0.4%; cockroaches strongly positive 0.4%.Protein allergen group: egg white had the highest and strongest sIgE positive rate: strong positive 0.4%, followed by positive shrimp 0.4%. The rate of positive beef sIgE was very low 3.8%. Carbohydrate allergen group: almonds have the highest sIgE positive rate and the strongest is 0.4% positive. 100% of patients had wheat, rye flour, barley flour, and oatmeal allergen tests negative and very low positive/low positive. 0.4% of patients were strongly positive for brewer's yeast allergen. Most of the patients were negative for milk and fruit allergens, only 0.4% of the patients were very strongly positive for pineapple; 0.4% positive for oranges; 0.4% were low positive for Alpha-lactalbumin, and 0.4% were low positive for Betaglobulin. Most of the patients tested negative for fungal allergens. Results from the logistic regression model showed the age of urticaria onset < 18 years, daily pruritus, duration of skin rash > 12 hours, duration of illness less than 1 year, total IgE > 100KU/l, and money Allergic history were independent prognostic factors with positive risk for 52 allergen test of study patients. Conclusion: The 52 allergen test is a valuable indication in the prophylactic treatment of patients with chronic urticaria with a history of allergies, age of onset of urticaria under 18 years of age, duration of illness less than 1 year, or total IgE > 100kU/l