SỰ BỘC LỘ THỤ THỂ ANDROGEN VÀ ESTROGEN TRONG UNG THƯ BIỂU MÔ TUYẾN VÚ XÂM NHẬP

Abstract

Androgen receptor (AR) links a transcription factor that controls specific genes involved in different, sometimes opposite, cellular processes: it can stimulate or suppress both cell proliferation and apoptosis, depending on the concurrent signaling pathways activated. Purpose: To Comment on some relationships between the expression of AR, ER and molecular type, NPI, risk group and postoperative stage of breast cancer. Methods: Tumor samples of 94 breast cancer patients were stained with AR and ER IHC markers to determine the immunophenotype and to assess association with some pathological features. Results: In the HER2 molecular type, the AR-ER- group was accounted for the highest proportion (55.9%) and in the breast cancer with basal type, phenotype AR+ ER- was accounted for the most common rate of 52.9%. AR-ER- accounts for the highest incidence of bad risk breast cancer (58.8%). Both AR-ER+ and AR+ ER+ stage I breast cancer were accounted for a higher rate than stage III (40.0 vs 13.3% and 29.8 vs 21.5%, respectively). Conclusion: The AR-ER- immunophenotype is often associated with the worst pathological characteristics.