MỘT SỐ ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG BỆNH NHÂN LUPUS BAN ĐỎ HỆ THỐNG CÓ TỔN THƯƠNG THẬN TẠI BỆNH VIỆN ĐA KHOA TỈNH PHÚ THỌ

Abstract

Objectives: The study aims to evaluate some clinical and laboratory features of patients with lupus nephritis and explore the relationship between some factors, therefor we can contribute to the diagnosis and prognosis earlier and more exactly. Methods: We performed a cross-sectional descriptive study on 101 patients with lupus nephritis treating at Phu Tho General Hospital from August 2021 to May 2022. Results: The percentage of women is 93%. The mean age is 39.8±14.1 (min 15, max 78). 13.9% of patients have nephrotic syndrome, 3% of cases are at the end stage renal failure requiring hemodialysis (3.0%). There are 35.6% of patients presenting with hematology injury. Hypertension occurs in 23.8% of cases. Patients with active nephritis lupus had significantly higher levels of urea, creatinine, uric acid, and CRP than patients who have been stable. 24h proteinuria is negatively correlated with albumin, total protein and serum iron and positively correlated with total cholesterol. The estimated glomerular filtration rate is negatively correlated with the uric acid levels, total cholesterol with p<0.05. Conclusion: Lupus nephritis is very common in patients with systemic lupus erythematosus, patients need to be fully and regularly examined to detect early manifestations of organ damages and disorders of hematology, biochemistry, immunity for appropriate treatment.