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Date Published: 19/02/2023
Abstract Views: 219
Views PDF: 146
DOI: https://doi.org/10.51298/vmj.v522i2.4384
Issue
Vol. 522 No. 2 (2023)
Section
Các bài báo
How to Cite
Đinh , T. T. H. ., Đỗ , N. S., & Bùi, V. H. . (2023). ROLE OF MULTIPLEX REAL-TIME PCR IN MORNITORING TREATMENT OF VENTILATION ASSOCIATED PNEUMONIA. Vietnam Medical Journal, 522(2). https://doi.org/10.51298/vmj.v522i2.4384

ROLE OF MULTIPLEX REAL-TIME PCR IN MORNITORING TREATMENT OF VENTILATION ASSOCIATED PNEUMONIA

Thị Thu Hương Đinh 1, Ngọc Sơn Đỗ 2,, Vũ Huy Bùi3
1 Thanh Nhan hospital
2 Bahc Mai hospital
3 Hanoi medical university

Main Article Content

Abstract

Objective: To analyze the role of multiplex real-time PCR in monitoring treatment of ventilator associated pneumonia (VAP). Patients and methods: 242 patients ≥ 18 years with suspected VAP were randomly divided into 2 groups: control group in whom sputum routine culture, routine bronchial fluid was carried out as usual and study group in whom multiplex real-time PCR was performed to guide the antibiotic treament. Results: The rate of appropriate antibiotic used in the study group was 89/121 (73.6%) patients, control group 59/121 (48.8%) patients with p< 0.05. The duration of mechanical ventilation; the length in  ICU stay and the the length of hospital stay in study group shorter than that in control group with statistically significant (p<0.05). The overall mortality rate in the study group was 42/121 (34.7%) patients, the control group was 59/121 (48.8%) patients with p=0.022. There was no statistically significant difference in mortality due to VAP in the study group 26/121 (21.5%) patients and in the control group 36/121 (39.8%) patients with p=0.141. It is necessary to apply multiplex realtime PCR to at least 6 patients to reduce one patient's death due to VAP. Conclusions: Using multiplex real-time PCR results to treat VAP increase the use of appropriate antibiotics; reduce length in  ICU stay and the the length of hospital stay.

Article Details

Keywords

Ventilation associated pneumonia, multiplex rea-ltime PCR

References

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