KHẢO SÁT VÀ ĐÁNH GIÁ VIỆC SỬ DỤNG KHÁNG SINH VANCOMYCIN TẠI BỆNH VIỆN ĐA KHOA ĐỒNG NAI

Abstract

Objectives: Vancomycin resistance has raised concerns about outcome prospects in the treatment of Gram-positive infections. The study was conducted at Dong Nai General Hospital from March 2019 to June 2019. Methods: retrospective study to evaluate the prescription and use of vancomycin in hospital. Results were determined and documented in 98 hospitalized patients. Information on patients was collected including: demographic, etiology and location of infection, microbiological data, dosage regimen, administration and renal toxicity of vancomycin. Results: The mean age of the patient and vancomycin treatment duration were 56 years and 9 days, respectively. Soft tissue and skin infections (44%) is main cause when using vancomycin. The main medical intervention is ventilator (28.6%). The number of patients with cured, better and reduced symtom is high (66.3%). The loading dose was applied in 13.3% of patients with a dose of 25.6 mg/kg. The majority of patient in the research used the initial dose of 1g/12-hour (78.6%) with normal renal fuction. 100% patient using intermittent IV infusion, 100% suitable for administration time and 63.2% suitable for infusion concentration. There were 7 patients with changes in serum creatinine (increase> 50% compared with baseline value), occurring at least after 7 -14 days of using vancomycin. Conclude: An entire program is needed to improve vancomycin use in hospitals. Vancomycin use should be monitored to optimize its use.