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Date Published: 07/03/2023
Abstract Views: 465
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DOI: https://doi.org/10.51298/vmj.v523i2.4508
Issue
Vol. 523 No. 2 (2023)
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Các bài báo
How to Cite
Đỗ, H. K. ., & Nguyễn, T. B. P. . (2023). ASSSESSING TREATMENT RESULTS OF SECOND-LINE PEMBROLIZUMAB FOR THE TREATMENT OF RECURRENT/METASTATIC NON-SMALL CELL LUNG CANCER. Vietnam Medical Journal, 523(2). https://doi.org/10.51298/vmj.v523i2.4508

ASSSESSING TREATMENT RESULTS OF SECOND-LINE PEMBROLIZUMAB FOR THE TREATMENT OF RECURRENT/METASTATIC NON-SMALL CELL LUNG CANCER

Hùng Kiên Đỗ1,, Thị Bích Phượng Nguyễn1
1 National cancer hopsital

Main Article Content

Abstract

Objective: Assessing the treatment results and adverse events of second-line pembrolizumab for the treatment of recurrent/metastatic non-small cell lung cancer patients at National Cancer Hospital from 06/2017 to 10/2022. Patients and method: Retrospective and prospective analyses of 22 patients diagnosed of recurrent/ metastatic non-small cell lung carcinoma treated with second-line pembrolizumab at National Cancer Hospital from 06/2017 to 10/2022. Results: Partial response rate was 31.8%, stable disease rate was 40.9%. Disease-control rate was 72.7%. Mean progression-free survival (PFS) was 5.25±2.22 months (range, 2.25-22 months). There was no significant difference in PFS among patients with clinical and subclinical features. Rates of hyperthyroidism and hypothyroidism were similar, accounted for 9.1% of cases. All grades were grade 1.  Conclusion: Second-line pembrolizumab improved the progression-free survival for the treatment of metastatic non-small lung cancer with a mean PFS of 5.25±2.22 months and disease-control rate was 72.7%.

Article Details

Keywords

Non-small cell lung cancer, recurrent/ metastatic stage, National Cancer Hospital, pembrolizumab monotherapy.

References

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