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Date Published: 07/03/2023
Abstract Views: 240
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DOI: https://doi.org/10.51298/vmj.v523i2.4548
Issue
Vol. 523 No. 2 (2023)
Section
Các bài báo
How to Cite
Hoàng, A. V. ., Phạm , N. L. ., Nguyễn, N. P. D. ., Diệp , H. V., Trương , M. N. ., & Nguyễn, H. L. T. (2023). STIMULTANEOUS DETERMINATION OF NARINGIN AND HESPERIDIN IN YOUNG POMELO POWDER BY LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY (LC-MS/MS). Vietnam Medical Journal, 523(2). https://doi.org/10.51298/vmj.v523i2.4548

STIMULTANEOUS DETERMINATION OF NARINGIN AND HESPERIDIN IN YOUNG POMELO POWDER BY LIQUID CHROMATOGRAPHY TANDEM MASS SPECTROMETRY (LC-MS/MS)

Anh Việt Hoàng1, Ngọc Liên Phạm 1, Ngọc Phương Diễm Nguyễn2, Hoàng Vũ Diệp 2, Minh Nhựt Trương 1, Hữu Lạc Thủy Nguyễn1,
1 University of Medicine and Pharmacy at Ho Chi Minh City
2 Institute of drug quality control Ho Chi Minh city

Main Article Content

Abstract

Objectives: Stimultaneous determination the content of naringin and hesperidin in young pomelo. Subjects and Methods: naringin an hesperidin in young pomelo. The qualitative procedure by HPLC-MS/MS was built and validated. Results: Chromatographic conditions: C8 column, mobile phase methanol – acetic acid 0.1 % (50 : 50), flow rate 0.6 ml/min, column temperature 30 oC, autosampler temperature 10oC, injection volume 5 μl, and MS/MS detector with ESI (-), MRM mode. Validation results proved the proposed method was suitable for determining the content of naringin and hesperidin in young pomelo powder. Conclusion: The procedure can be applied for stimultaneous determination the content of naringin and hesperidin in young pomelo.

Article Details

Keywords

naringin, hesperidin, young pomelo, LC-MS/MS.

References

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