MỘT SỐ CHỈ SỐ HUYẾT HỌC, ĐÔNG MÁU VÀ MỐI LIÊN QUAN Ở BỆNH NHÂN UNG THƯ PHỔI NGUYÊN PHÁTTẠI VIỆN HUYẾT HỌC – TRUYỀN MÁU TRUNG ƯƠNG GIAI ĐOẠN 2020 – 2022

Abstract

Despite the fact that primary lung cancer is a malignant disease that doesn’t come from hematopoietic system, there are plenty of researches provide information on the diverse alterations in hematological and hemostatic disorder during the growth of malignant tumor as well as the process of treating cancer patients. Objectives: (1) Describe hematological and hemostatic features in lung cancer patients admitted National Institute of Hematology and Blood Transfusion in 2020 – 2022. (2) Evaluate the correlation among hematological, hemostatic and other features of research subjects. Methods and materials: 34 patients admitting the first time at the research location and already been diagnosed with lung cancer before admission. Results: Age group 50-64 years old accounts for the highest figure with 76.5%. The ratio of men to women is about 8:1. White blood cells elevate in over 40% patients, average of 16.13 ± 23.29 G/L. Almost 50% patients increasing platelets with average of 511.35 ± 511.67 G/L. Intermediate and high risks VTE are seen in 60% lung cancer patients based on Khorana score who need prophylaxis. D-dimer rises in 82% subjects while Fibrinogen increases in 80% subjects, with the average numbers are 2061.97 ± 2180.45ng/ml and 5.22 ± 1.33 g/l respectively. There is no statistical difference seen in comparison of hematological and hemostatic values between group patients treated and the non-treated group. The concentration of Fibrinogen and the number of platelets among research subjects follow a positive correlation, with r=0,6. Conclusion: Subjects of research suffer from various hematological, hemostatic elevation and risks of VTE based on Khorana score with positive correlations among some features. There is no correlation between the figure and treatment condition. Patients experiencing elevated white blood cells and platelets with unknown reasons should screen for hemostatic abnormalities and lung cancer.