CLINICAL AND LABORATORY CHARACTERISTICS OF SEVERE ALCOHOL WITHDRAWAL SYNDROME

Đặng Thị Xuân, Đỗ Ngọc Sơn

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Abstract

Objective: to assess clinical features and laboratory abnormalities of severe alcohol withdrawal syndrome. Subjects and Methods: An observational study on 38 patients with severe alcohol withdrawal syndrome (CIWA-Ar score ≥20) treated at Poison Control Center of Bach Mai Hospital from January 2018 to July 2018. Results: The study patients were all male (100%), the mean age was 47.6 ± 12.6 years old, mainly from 40 to 60 years old (68.4%), the average duration of alcoholism was 18.7 ± 8.55 years; 63.2% had drunk 500-700ml/day. The alcohol withdrawal syndrome lasted for an average of 3.8 days. Clinical features: patient admitted to hospital had all signs in CIWA-Ar score: tremor (100%), anxiety (100%), sweating (97.4%), agitation (92.1%), nausea and vomiting (28.9%), headache (15.8%). Psychiastric disorders: delusion of hearing (92.1%), vision (89.5%), touch (23.7%). Orientation disorder in 76.3% of patients. Complications of pneumonia (39.5%) and 15.8% of patients must be ventilated. Laboratory features: Increased CK, AST, ALT, lactate. Conclusion: Severe alcohol withdrawal syndrome present many serious symptoms and complications, requiring resuscitation and treatment in intensive care units.

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