Article Sidebar

PDF
Date Published: 07/03/2023
Abstract Views: 255
Views PDF: 165
DOI: https://doi.org/10.51298/vmj.v523i2.4566
Issue
Vol. 523 No. 2 (2023)
Section
Các bài báo
How to Cite
Trần , K. S. ., Ngô , H. T. ., Trần , Đặng Đăng K. ., Phạm , T. M. ., Trương, B. Ân ., Mai , L. T. ., & Nguyễn, T. K. . (2023). THE STUDY OF THE RESULTS OF BLOOD HOMOCYSTEINE CONTENTS AND BLOOD PRESSURE CONTROL IN PATIENTS WITH NEWLY DIAGNOSED HYPERTENSION BY PERINDOPRIL. Vietnam Medical Journal, 523(2). https://doi.org/10.51298/vmj.v523i2.4566

THE STUDY OF THE RESULTS OF BLOOD HOMOCYSTEINE CONTENTS AND BLOOD PRESSURE CONTROL IN PATIENTS WITH NEWLY DIAGNOSED HYPERTENSION BY PERINDOPRIL

Kim Sơn Trần 1,, Hoàng Toàn Ngô 1, Đặng Đăng Khoa Trần 1, Thị Minh Phạm 1, Bảo Ân Trương2, Long Thủy Mai 1, Trung Kiên Nguyễn1
1 Can Tho University of Medicine and Pharmacy Hospital
2 Angiang Heart Hospital

Main Article Content

Abstract

Objective: To evaluate the control results of blood homocysteine levels and blood pressure in patients with newly detected hypertension treated with perindopril. Subjects and methods: A cross-sectional descriptive study was conducted on 105 newly discovered hypertensive patients at the Can Tho University of Medicine and Pharmacy Hospital from 2017–2018. Results: The mean blood homocysteine concentration after treatment with perindopril was lower than before treatment. 4.33 mol/L, 95% confidence interval: 3.69–4.97, p 0.001. After 6 weeks of treatment with perindopril, the proportion of patients with hyperhomocysteinemia decreased from 74.3% to 40.0% (p<0.05), and the proportion of patients with normal blood pressure accounted for 70.5% of the total. Grade 1 blood pressure decreased from 61.0% to 25.7%, and grade 2 hypertension decreased from 17.1% to 3.8%. The proportion of simultaneous control of both blood pressure and blood homocysteine was 62.8%. Conclusion: Perindopril is effective in controlling both blood pressure and blood homocysteine levels in patients with newly discovered hypertension.

Article Details

Keywords

hypertension, blood homocysteine

References

1. Võ Tam, Nguyễn Thị Lộc (2012), "Nghiên cứu các mối tương quan của Homocystein huyết tương ở bệnh nhân suy thận giai đoạn cuối lọc màng bụng", Tạp chí Y học thực hành, 805, pp.12-15.
2. James P. A., Oparil S., Carter B. L. et al. (2014), "Evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8)", Jama, 311 (5), pp.507-520.
3. Poduri A., Kaur J., Thakur J. S. et al. (2008), "Effect of ACE inhibitors and beta-blockers on homocysteine levels in essential hypertension", J Hum Hypertens, 22 (4), pp.289-294.
4. Rayburn W. F. (1998), "Sixth report of the Joint National Committee on Prevention, Detection, Evaluation and Treatment of High Blood Pressure. A summary", J Reprod Med, 43 (5), pp.444-450.
5. Thomson A., Greenacre M. (2007), "Perindopril: the evidence of its therapeutic impact in hypertension", Core Evid, 2 (1), pp.63-79.
6. Tropeano A. I., Boutouyrie P., Pannier B. et al. (2006), "Brachial pressure-independent reduction in carotid stiffness after long-term angiotensin-converting enzyme inhibition in diabetic hypertensives", Hypertension, 48 (1), pp.80-86.
7. Westphal S., Rading A., Luley C. et al. (2003), "Antihypertensive treatment and homocysteine concentrations", Metabolism, 52 (3), pp.261-263.
8. Fu J., Tang H. Q., Qin X. H. et al. (2009), "Efficacy of enalapril combined with folic acid in lowering blood pressure and plasma homocysteine level", Zhonghua Yi Xue Za Zhi, 89 (31), pp.2179-2183.
9. Zhao F., Li J. P., Wang S. Y. et al. (2008), "The effect of baseline homocysteine level on the efficacy of enalapril maleate and folic acid tablet in lowering blood pressure and plasma homocysteine", Zhonghua Yi Xue Za Zhi, 88 (42), pp.2957-2961.